(19)

(11)

EP 3 021 880 A1

(12)

(43) Date of publication: 25.05.2016 Bulletin 2016/21 (21) Application number: 14739200.5 (22) Date of filing: 16.07.2014

(51) International Patent Classification (IPC):  A61L 27/18(2006.01) A61L 27/52(2006.01) C12N 5/00(2006.01) A61L 27/38(2006.01) A61L 27/56(2006.01) (86) International application number: PCT/EP2014/065301 (87) International publication number: WO 2015/007797 (22.01.2015 Gazette 2015/03)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 17.07.2013 EP 13306027 17.07.2013 US 201313944245 (71) Applicants: Institut National de la Santé et de la Recherche Médicale 75013 Paris (FR) Université de Strasbourg 67000 Strasbourg (FR)	(72) Inventors: BENKIRANE-JESSEL, Nadia F-67000 Strasbourg (FR) EAP, Sandy F-67000 Strasbourg (FR) KELLER, Laetitia F-67000 Strasbourg (FR) (74) Representative: Blot, Philippe Robert Emile  Cabinet Lavoix 2, place d'Estienne d'Orves 75441 Paris Cedex 09 75441 Paris Cedex 09 (FR)