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(11)

EP 3 024 500 A1

(12)

(43) Date of publication: 01.06.2016 Bulletin 2016/22 (21) Application number: 14829114.9 (22) Date of filing: 25.07.2014

(51) International Patent Classification (IPC):  A61K 49/14(2006.01) A61K 49/06(2006.01) A61K 49/12(2006.01) A61P 35/00(2006.01) (86) International application number: PCT/US2014/048277 (87) International publication number: WO 2015/013665 (29.01.2015 Gazette 2015/04)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 25.07.2013 US 201361858550 P (71) Applicant: Sloan-kettering Institute For Cancer Research New York, NY 10065 (US)	(72) Inventors: REINER, Thomas Weehawken, New Jersey 07086 (US) BRAND, Christian New York, New York 10065 (US) LEWIS, Jason New York, New York 10065 (US) WEBER, Wolfgang Larchmont, New York 10538 (US) (74) Representative: Bibus, Claudia R.  E. Blum & Co. AG Vorderberg 11 8044 Zürich 8044 Zürich (CH)