(19)

(11)

EP 3 038 616 A2

(12)

(88) Date of publication A3: 05.03.2015 (43) Date of publication: 06.07.2016 Bulletin 2016/27 (21) Application number: 14841276.0 (22) Date of filing: 26.08.2014

(51) International Patent Classification (IPC):  A61K 31/35(2006.01) A61P 31/12(2006.01) A61K 38/16(2006.01) A61P 29/00(2006.01) (86) International application number: PCT/US2014/052635 (87) International publication number: WO 2015/031313 (05.03.2015 Gazette 2015/09)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 26.08.2013 US 201361869823 P (71) Applicant: The Medicines Company Parsippany, NJ 07054 (US)	(72) Inventors: MOECK, Gregory St. Laurent, Québec H4L 2R3 (CA) ARHIN, Francis Laval, Québec H7W 1S1 (CA) (74) Representative: MacLean, Martin Robert et al Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG The Shard 32 London Bridge Street London SE1 9SG (GB)