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(11)

EP 3 039 022 A1

(12)

(43) Date of publication: 06.07.2016 Bulletin 2016/27 (21) Application number: 14841043.4 (22) Date of filing: 29.08.2014

(51) International Patent Classification (IPC):  C07D 417/04(2006.01) C07D 231/06(2006.01) C07D 213/06(2006.01) C07D 277/66(2006.01) A61K 31/426(2006.01) C07D 417/14(2006.01) C07D 277/24(2006.01) C07D 277/22(2006.01) A61K 31/4439(2006.01) A61P 3/00(2006.01) (86) International application number: PCT/US2014/053334 (87) International publication number: WO 2015/031710 (05.03.2015 Gazette 2015/09)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 29.08.2013 US 201314013918 11.10.2013 US 201314052074 05.05.2014 US 201414270130 (71) Applicant: Baylor College Of Medicine Houston, TX 77030-2504 (US)	(72) Inventors: UESUGI, Motonari Neyagawa-shi Osaka 572-0867 (JP) WAKIL, Salih, J. Houston, TX 77024 (US) ABU-ELHEIGA, Lutfi Houston, TX 77025 (US) WATANABE, Mizuki Uji-shi 611-0011 (JP) (74) Representative: Beck Greener  Fulwood House 12 Fulwood Place London WC1V 6HR London WC1V 6HR (GB)