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(11)

EP 3 043 813 A2

(12)

(88) Date of publication A3: 05.11.2015 (43) Date of publication: 20.07.2016 Bulletin 2016/29 (21) Application number: 14834927.7 (22) Date of filing: 08.08.2014

(51) International Patent Classification (IPC):  A61K 38/37(2006.01) C12P 21/06(2006.01) C12N 5/14(2006.01) C12P 21/04(2006.01) C12N 5/07(2010.01) (86) International application number: PCT/US2014/050411 (87) International publication number: WO 2015/021423 (12.02.2015 Gazette 2015/06)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 08.08.2013 US 201361863810 P (71) Applicant: Biogen MA Inc. Cambridge, MA 02142 (US)	(72) Inventors: ZHU, Lily Belmont, Massachusetts 02478 (US) KOLE, Anxhela Quincy, Massachusetts 02169 (US) KULMAN, John Belmont, Massachusetts 02478 (US) ACOSTA, Marisol Worcester, Massachusetts 01610 (US) (74) Representative: Miller, David James et al Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG London SE1 9SG (GB)