(19)
(11) EP 3 057 597 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
14.08.2019 Bulletin 2019/33

(45) Mention of the grant of the patent:
05.06.2019 Bulletin 2019/23

(21) Application number: 14781539.3

(22) Date of filing: 07.10.2014
(51) International Patent Classification (IPC): 
A61K 31/7048(2006.01)
A61K 31/593(2006.01)
A61P 19/02(2006.01)
A61K 31/12(2006.01)
A61K 45/06(2006.01)
(86) International application number:
PCT/EP2014/071452
(87) International publication number:
WO 2015/055468 (23.04.2015 Gazette 2015/16)

(54)

ANTI-INFLAMMATORY PHYTONUTRIENTS FOR USE IN THE TREATMENT OR PREVENTION OF SYNOVITIS

ENTZÜNDUNGSHEMMENDE PHYTONÄHRSTOFFEN ZUR VERWENDUNG BEI DER BEHANDLUNG ODER PRÄVENTION VON SYNOVITIS

PHYTONUTRIMENTS ANTI-INFLAMMATOIRES SERVANT AU TRAITEMENT OU À LA PRÉVENSION DE LA SYNOVITE


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 14.10.2013 US 201361890626 P

(43) Date of publication of application:
24.08.2016 Bulletin 2016/34

(60) Divisional application:
19175837.4

(73) Proprietor: Société des Produits Nestlé S.A.
1800 Vevey (CH)

(72) Inventors:
  • HORCAJADA, Marie Noëlle
    01170 Echenevex (FR)
  • MEMBREZ, Fanny
    1053 Cugy (CH)
  • OFFORD CAVIN, Elizabeth
    1820 Montreux (CH)

(74) Representative: Chautard, Cécile 
Société des Produits Nestlé S.A. Avenue Nestlé 55
1800 Vevey
1800 Vevey (CH)


(56) References cited: : 
WO-A1-2014/191447
WO-A2-03/068171
   
  • SANCHEZ CHRISTELLE ET AL: "Oleuropein Or Rutin Consumption Decreases The Spontaneous Development Of OA In Hartley Guinea Pig", ARTHRITIS & RHEUMATISM, vol. 65, no. Suppl. 10, Sp. Iss. SI, 1 October 2013 (2013-10-01), pages S32-S33, XP002735451, & 77TH ANNUAL MEETING OF THE AMERICAN-COLLEGE-OF-RHEUMATOLOGY / 48TH ANNUAL MEETING OF THE ASSOCIATION; SAN DIEGO, CA, USA; OCTOBER 25 -30, 2013
  • KAMARUDIN T A ET AL: "Protective effect of curcumin on experimentally induced arthritic rats: Detailed histopathological study of the joints and white blood cell count", EXCLI JOURNAL 2012 LEIBNIZ RES. CENTRE FOR WORKING ENVIRON. AND HUMAN FACTORS DEU, vol. 11, 2012, pages 226-236, XP002735452, ISSN: 1611-2156
  • MOON D O ET AL: "Curcumin attenuates inflammatory response in IL-1<2>-induced human synovial fibroblasts and collagen-induced arthritis in mouse model", INTERNATIONAL IMMUNOPHARMACOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 10, no. 5, 1 May 2010 (2010-05-01), pages 605-610, XP026996010, ISSN: 1567-5769 [retrieved on 2010-02-23]
  • PARK CHEOL ET AL: "Curcumin induces apoptosis and inhibits prostaglandin E-2 production in synovial fibroblasts of patients with rheumatoid arthritis", INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 20, no. 3, September 2007 (2007-09), pages 365-372, XP002735453, ISSN: 1107-3756
  • PIPITONE NICOLÒ ET AL: "Recent advances in the treatment of psoriatic arthritis.", EXPERT OPINION ON THERAPEUTIC PATENTS APR 2004, vol. 14, no. 4, April 2004 (2004-04), pages 509-525, XP002735454, ISSN: 1354-3776
  • KAUSS TINA ET AL: "Rutoside decreases human macrophage-derived inflammatory mediators and improves clinical signs in adjuvant-induced arthritis.", ARTHRITIS RESEARCH & THERAPY 2008, vol. 10, no. 1, 2008, page R19, XP002735455, ISSN: 1478-6362
  • IMPELLIZZERI DANIELA ET AL: "Oleuropein aglycone, an olive oil compound, ameliorates development of arthritis caused by injection of collagen type II in mice.", THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS DEC 2011, vol. 339, no. 3, December 2011 (2011-12), pages 859-869, XP002735456, ISSN: 1521-0103
  • M.-N. HORCAJADA ET AL: "Oleuropein or rutin consumption decreases the spontaneous development of osteoarthritis in the Hartley guinea pig", OSTEOARTHRITIS AND CARTILAGE, vol. 23, no. 1, 8 September 2014 (2014-09-08), pages 94-102, XP55166415, ISSN: 1063-4584, DOI: 10.1016/j.joca.2014.08.016
  • "2013 Annual Meeting Abstract Supplement", ARTHRITIS & RHEUMATISM, vol. 65, no. S10, 1 October 2013 (2013-10-01), DOI: onlinelibrary.wiley.com/doi/abs/10.1002/ar t.38216
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).