(19)
(11) EP 3 060 569 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
24.11.2021 Bulletin 2021/47

(45) Mention of the grant of the patent:
02.12.2020 Bulletin 2020/49

(21) Application number: 13783630.0

(22) Date of filing: 22.10.2013
(51) International Patent Classification (IPC): 
A61K 31/66(2006.01)
 C07F 9/53(2006.01)
(52) Cooperative Patent Classification (CPC):
A61P 27/02; A61P 11/14; A61P 17/00; A61P 1/04; A61P 3/02; A61P 15/00; A61K 31/66; A61P 25/14; A61P 25/28; A61P 11/04; A61P 25/00; A61P 11/02; C07F 9/5304; A61P 25/24; A61P 17/06; C07F 9/532
(86) International application number:
PCT/GB2013/052750
(87) International publication number:
WO 2015/059432 (30.04.2015 Gazette 2015/17)

(54)

DI-ISOPROPYL-PHOSPHINOYL-ALKANE (DAPA) COMPOUNDS AS TOPICAL AGENTS FOR THE TREATMENT OF SENSORY DISCOMFORT

DI-ISOPROPYL-PHOSPHINOYL-ALKAN (DAPA)-VERBINDUNGEN ALS TOPISCHES MITTEL ZUR BEHANDLUNG VON SENSORISCHEN BESCHWERDEN

COMPOSÉS DI-ISOPROPYL-PHOSPHINOYL-ALCANES (DAPA) EN TANT QU'AGENTS TOPIQUES POUR LE TRAITEMENT D'UNE GÊNE SENSORIELLE

(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(43) Date of publication of application:
31.08.2016 Bulletin 2016/35

(73) Proprietor: IVIEW Therapeutics, Inc.
Doylestown, PA 18902 (US)

(72) Inventor:
  • Wei, Edward Tak
    Berkeley, CA 94708-1237 (US)

(74) Representative: FRKelly 
27 Clyde Road
Dublin D04 F838
Dublin D04 F838 (IE)


(56) References cited: : 
US-A- 4 070 496
 US-A1- 2005 059 639
   
  • T. H. SIDDALL ET AL: "Simplified Preparation of Some Trisubstituted Phosphine Oxides.", JOURNAL OF CHEMICAL & ENGINEERING DATA, vol. 10, no. 3, 1 July 1965 (1965-07-01), pages 303-305, XP055107019, ISSN: 0021-9568, DOI: 10.1021/je60026a031
  • WATSON H R ET AL: "NEW COMPOUNDS WITH THE MENTHOL COOLING EFFECT", JOURNAL OF THE SOCIETY COSMETIC CHEMISTS, SOCIETY OF COSMETIC CHEMISTS, US, vol. 29, no. 4, 1 January 1978 (1978-01-01), pages 185-200, XP009045124, ISSN: 0037-9832
  • JEE MYUNG YANG ET AL: "A novel TRPM8 agonist relieves dry eye discomfort", BMC OPHTHALMOLOGY, vol. 17, no. 1, 26 June 2017 (2017-06-26), XP055604373, DOI: 10.1186/s12886-017-0495-2
  • D. A. ANDERSSON ET AL: "Modulation of the Cold-Activated Channel TRPM8 by Lysophospholipids and Polyunsaturated Fatty Acids", THE JOURNAL OF NEUROSCIENCE, vol. 27, no. 12, 21 March 2007 (2007-03-21), pages 3347-3355, XP055651702, US ISSN: 0270-6474, DOI: 10.1523/JNEUROSCI.4846-06.2007
 
Remarks:
The file contains technical information submitted after the application was filed and not included in this specification
 
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).