METHOD FOR MAKING ANTIBODY FC-HETERODIMERIC MOLECULES USING ELECTROSTATIC STEERING EFFECTS

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EP 3 061 770 B8

(12)	CORRECTED EUROPEAN PATENT SPECIFICATION
	Note: Bibliography reflects the latest situation

(15)	Correction information:
	Corrected version no 1 (W1 B1)

(48)	Corrigendum issued on:
	12.02.2020 Bulletin 2020/07

(45)	Mention of the grant of the patent:
	11.12.2019 Bulletin 2019/50

(21)	Application number: 15187984.8

(22)	Date of filing: 06.01.2009

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International Patent Classification (IPC):

C07K 16/46^(2006.01)

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METHOD FOR MAKING ANTIBODY FC-HETERODIMERIC MOLECULES USING ELECTROSTATIC STEERING EFFECTS

VERFAHREN ZUR HERSTELLUNG VON FC-HETERODIMEREN ANTIKÖRPERMOLEKÜLEN ANHAND ELEKTROSTATISCHER STEUEREFFEKTE

PROCÉDÉ DE FABRICATION DE MOLÉCULES HÉTÉRODIMÈRES FC D'ANTICORPS UTILISANT LES EFFETS DE CONDUITE ÉLECTROSTATIQUE

(84)	Designated Contracting States:
	AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR
	Designated Extension States:
	AL BA RS

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Priority:

07.01.2008 US 19569 P
05.12.2008 US 120305 P

(43)	Date of publication of application:
	31.08.2016 Bulletin 2016/35

(60)	Divisional application:
	19214899.7

(62)	Application number of the earlier application in accordance with Art. 76 EPC:
	09700643.1 / 2235064

(73)	Proprietor: Amgen Inc.
	Thousand Oaks, CA 91320-1799 (US)

(72)	Inventors:
	KANNAN, Gunasekaran Issaquah, Washington 98029 (US) WITTEKIND, Michael Bainbridge Island, Washington 98110 (US) YAN, Wei Sammamish, Washington 98075 (US) PENTONY, Martin Seattle, Washington 98146 (US)

(74)	Representative: Care, Alison et al
	Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL London WC1X 8NL (GB)

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References cited: :

WO-A-2007/110205

SINHA NEETI ET AL: "ELECTROSTATICS IN PROTEIN BINDING AND FUNCTION", CURRENT PROTEIN AND PEPTIDE SCIENCE, BENTHAM SCIENCE PULBISHERS, NL, vol. 3, no. 6, 1 December 2002 (2002-12-01), pages 601-614, XP008077600, ISSN: 1389-2037
ZHU Z ET AL: "REMODELING DOMAIN INTERFACES TO ENHANCE HETERODIMER FORMATION", PROTEIN SCIENCE, WILEY, US, vol. 6, no. 4, 1 April 1997 (1997-04-01), pages 781-788, XP000929847, ISSN: 0961-8368

Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).