(19)

(11)

EP 3 063 268 A2

(12)

(88) Date of publication A3: 13.08.2015 (43) Date of publication: 07.09.2016 Bulletin 2016/36 (21) Application number: 14857034.4 (22) Date of filing: 21.05.2014

(51) International Patent Classification (IPC):  C12N 5/02(2006.01) A61K 31/41(2006.01) C12N 5/071(2010.01) C07D 403/00(2006.01) (86) International application number: PCT/US2014/038993 (87) International publication number: WO 2015/065524 (07.05.2015 Gazette 2015/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 01.11.2013 US 201361962158 P 30.12.2013 US 201313998974 (71) Applicant: Janssen Biotech, Inc. Horsham, PA 19044-3607 (US)

(72) Inventors: FRYER, Benjamin Horsham, PA 19044 (US) LANIAUSKAS, Daina Horsham, PA 19044 (US) BLACKMOORE, Marcia Horsham, PA 19044 (US) WANG, Haiyun Horsham, PA 19044 (US) LILOVA, Kostadinka Spring House, PA 19477 (US) NELSON, Shelley Titusville, NJ 08560 (US) ROSOCHA, Elizabeth Raritan, NJ 08869 (US) (74) Representative: Carpmaels & Ransford LLP  One Southampton Row London WC1B 5HA London WC1B 5HA (GB)