| (19) |
 |
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(11) |
EP 3 064 512 A3 |
| (12) |
EUROPEAN PATENT APPLICATION |
| (88) |
Date of publication A3: |
|
19.10.2016 Bulletin 2016/42 |
| (43) |
Date of publication A2: |
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07.09.2016 Bulletin 2016/36 |
| (22) |
Date of filing: 09.01.2009 |
|
| (51) |
International Patent Classification (IPC):
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| (84) |
Designated Contracting States: |
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AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO
PL PT RO SE SI SK TR |
| (30) |
Priority: |
11.01.2008 JP 2008004423
|
| (62) |
Application number of the earlier application in accordance with Art. 76 EPC: |
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09700588.8 / 2241578 |
| (71) |
Applicants: |
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- The University of Tokyo
Bunkyo-ku,
Tokyo 113-8654 (JP)
- CHUGAI SEIYAKU KABUSHIKI KAISHA
Tokyo 115-8543 (JP)
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| (72) |
Inventors: |
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- ABURATANI, Hiroyuki
Bunkyo-ku
Tokyo 113-8654 (JP)
- TSUTSUMI, Shuichi
Bunkyo-ku
Tokyo 113-8654 (JP)
- NISHIMURA, Kunihiro
Bunkyo-ku
Tokyo 113-8654 (JP)
- SAKUMOTO, Hirofumi
Meguro-ku
Tokyo 153-0041 (JP)
- KAWAI, Shigeto
Meguro-ku
Tokyo 153-0041 (JP)
|
| (74) |
Representative: Power, David |
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J A Kemp
14 South Square
Gray's Inn
London WC1R 5JJ
London WC1R 5JJ (GB) |
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(57) Disclosed is an antibody capable of binding to Claudin-6 (CLDN6) which is expressed
on the surface of a cell membrane. The antibody can recognize human CLDN6 occurring
on the surface of a cell membrane in its native form, and has a cytotoxic activity
(e.g., ADCC activity and a CDC activity) against a cancer cell line which expresses
human CLDN6 at a high level. A conjugate of the antibody and a toxin has an inhibitory
activity on the cell proliferation of a cancer cell line which expresses human CLDN6
at a high level. The expression of human CLDN6 is not observed in a normal tissue,
but is increased in a tumor tissue (e.g., pulmonary adenocarcinoma, gastric cancer,
ovarian cancer). The anti-CLDN6 antibody is expected to be highly accumulated in tumor
in which human CLDN6 has been expressed at a high level, and therefore can be used
as an extremely effective anti-tumor agent.