(19)

(11)

EP 3 065 768 A2

(12)

(88) Date of publication A3: 16.07.2015 (43) Date of publication: 14.09.2016 Bulletin 2016/37 (21) Application number: 14856815.7 (22) Date of filing: 04.11.2014

(51) International Patent Classification (IPC):  A61K 38/36(2006.01) A61P 7/04(2006.01) C07K 14/745(2006.01) (86) International application number: PCT/US2014/063898 (87) International publication number: WO 2015/066700 (07.05.2015 Gazette 2015/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 04.11.2013 US 201361899544 P 26.02.2014 US 201461944915 P (71) Applicants: The Regents of the University of California Oakland, CA 94607 (US) The Scripps Research Institute La Jolla, CA 92037 (US)	(72) Inventors: VON DRYGALSKI, Annette La Jolla, CA 92037 (US) GALE, Andrew San Diego, CA 92126 (US) GRIFFIN, John, H. Del Mar, CA 92014 (US) MOSNIER, Laurent San Diego, CA 92123 (US) (74) Representative: Stephens, Clare Jean  Page White & Farrer Bedford House John Street London WC1N 2BF London WC1N 2BF (GB)