(19)
(11) EP 3 065 782 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
26.05.2021 Bulletin 2021/21

(45) Mention of the grant of the patent:
14.04.2021 Bulletin 2021/15

(21) Application number: 14861026.4

(22) Date of filing: 04.11.2014
(51) International Patent Classification (IPC): 
A61P 21/00(2006.01)
A61K 9/00(2006.01)
 B82Y 5/00(2011.01)
A61K 31/13(2006.01)
(86) International application number:
PCT/US2014/063963
(87) International publication number:
WO 2015/069669 (14.05.2015 Gazette 2015/19)

(54)

NANOSTRUCTURE CONJUGATES FOR MODULATION OF LOCATION-SPECIFIC SUBTYPES OF RECEPTORS AND ION CHANNELS

NANOSTRUKTURKONJUGATE ZUR MODULATION STANDORTSPEZIFISCHER SUBTYPEN VON REZEPTOREN UND IONENKANÄLEN

CONJUGUÉS NANOSTRUCTURÉS POUR LA MODULATION DE SOUS-TYPES SPÉCIFIQUES D'UN EMPLACEMENT DE RÉCEPTEURS ET DE CANAUX IONIQUES

(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 05.11.2013 US 201361962335 P

(43) Date of publication of application:
14.09.2016 Bulletin 2016/37

(73) Proprietor: Molokanova, Elena
Encinitas, California 92024 (US)

(72) Inventors:
  • SAVTCHENKO, Alex
    Encinitas, California 92024 (US)
  • BRAUN, Gary
    Santa Barbara, California 93109 (US)
  • Molokanova, Elena
    Encinitas, California 92024 (US)

(74) Representative: Snaith, James Michael 
Kilburn & Strode LLP Lacon London 84 Theobalds Road
London WC1X 8NL
London WC1X 8NL (GB)


(56) References cited: : 
US-A1- 2008 206 146
 US-A1- 2010 330 167
   
  • Lisa Maus: "Inaugural-Dissertation: Entwicklung stabiler Gold Nanopartikel-Peptid- Konjugate zur Untersuchung von Rezeptor-Liganden Wechselwirkungen im zellulären System", , 24 May 2010 (2010-05-24), pages 1-165, XP055370518, DOI: 10.11588/heidok.00010668 Retrieved from the Internet: URL:http://archiv.ub.uni-heidelberg.de/vol ltextserver/10668/1/Dissertation_Lisa_Maus .pdf [retrieved on 2017-05-09]
  • MAUS L ET AL: "Conjugation of Peptides to the Passivation Shell of Gold Nanoparticles for Targeting of Cell- Surface Receptors", ACS NANO, AMERICAN CHEMICAL SOCIETY, US, vol. 4, no. 11, 23 November 2010 (2010-11-23), pages 6617-6628, XP002714555, ISSN: 1936-0851, DOI: 10.1021/NN101867W [retrieved on 2010-10-12]
  • FRIESE A ET AL: "Increase of the duration of the anticonvulsive activity of a novel NMDA receptor antagonist using poly(butylcyanoacrylate) nanoparticles as a parenteral controlled release system", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM, NL, vol. 49, no. 2, 1 March 2000 (2000-03-01), pages 103-109, XP004257143, ISSN: 0939-6411, DOI: 10.1016/S0939-6411(99)00073-9
  • BHASKAR ET AL.: 'Multifunctional Nanocarriers for diagnostics, drug delivery and targeted treatment across blood-brain barrier: perspectives on tracking and neuroimaging?' PARTICLE AND FIBRE TOXICOLOGY vol. 7, no. 3, 03 March 2010, pages 1 - 25, XP021069139
  • 'Chemical synapse - Structure' WIKIPEDIA 02 January 2015, XP055343081 Retrieved from the Internet: <URL:http://en.wikipedia.org/wiki/Chemical_ synapse#Structure>
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).