(19)

(11)

EP 3 066 131 A1

(12)

(43) Date of publication: 14.09.2016 Bulletin 2016/37 (21) Application number: 14810051.4 (22) Date of filing: 07.11.2014

(51) International Patent Classification (IPC):  C07K 16/32(2006.01) A61P 35/00(2006.01) A01K 67/027(2006.01) A61K 39/395(2006.01) A61P 35/02(2006.01) (86) International application number: PCT/US2014/064657 (87) International publication number: WO 2015/070078 (14.05.2015 Gazette 2015/19)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 07.11.2013 US 201361901210 P (71) Applicants: Memorial Sloan-Kettering Cancer Center New York, NY 10065 (US) Eureka Therapeutics, Inc. Emeryville, CA 94608 (US) Novartis AG 4056 Basel (CH)

(72) Inventors: SCHEINBERG, David New York, NY 10025 (US) VEOMETT, Nicholas New York, NY 10065 (US) LIU, Hong El Sobrante, CA 94803 (US) XIANG, Jingyi Walnut Creek, CA 94597 (US) LIU, Cheng Oakland, CA 94618 (US) DAO, Tao New York, NY 10128 (US) HUET, Heather, Adkins Cambridge, MA 02139 (US) (74) Representative: Clements, Andrew Russell Niel et al Schlich 9 St Catherine's Road Littlehampton, West Sussex BN17 5HS Littlehampton, West Sussex BN17 5HS (GB)