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(11)

EP 3 068 343 A1

(12)

(43) Date of publication: 21.09.2016 Bulletin 2016/38 (21) Application number: 14862748.2 (22) Date of filing: 18.04.2014

(51) International Patent Classification (IPC):  A61F 2/16(2006.01) A61F 2/12(2006.01) A61L 27/14(2006.01) A61F 2/26(2006.01) (86) International application number: PCT/US2014/034725 (87) International publication number: WO 2015/073060 (21.05.2015 Gazette 2015/20)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 14.11.2013 US 201361904200 P 22.11.2013 US 201361907581 P 24.12.2013 US 201361920619 P 24.12.2013 US 201361920623 P (71) Applicants: California Institute of Technology Pasadena, CA 91125 (US) University of Southern California Los Angeles, CA 90015 (US)

(72) Inventors: DEBOER, Charles Pasadena, California 91107 (US) TAI, Yu-Chong Pasadena, California 91107 (US) HUMAYUN, Mark Glendale, California 91206 (US) SHI, Wendian Monrovia, California 91016 (US) (74) Representative: Fyfe, Fiona Allison Watson  Murgitroyd & Company Scotland House 165-169 Scotland Street Glasgow G5 8PL Glasgow G5 8PL (GB)