(19)
(11) EP 3 068 407 A1

(12)

(43) Date of publication:
21.09.2016 Bulletin 2016/38

(21) Application number: 14805434.9

(22) Date of filing: 10.11.2014
(51) International Patent Classification (IPC): 
A61K 31/713(2006.01)
A61P 21/00(2006.01)
 C12N 15/113(2010.01)
(86) International application number:
PCT/US2014/064837
(87) International publication number:
WO 2015/070158 (14.05.2015 Gazette 2015/19)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME

(30) Priority: 11.11.2013 US 201361902358 P

(71) Applicants:
  • Sirna Therapeutics, Inc.
    Cambridge, MA 02142 (US)
  • Sepp-Lorenzino, Laura
    Cambridge, MA 02142 (US)
  • Jadhav, Vasant
    Cambridge, MA 02142 (US)
  • Brown, Duncan
    Berkeley, CA 94708 (US)

(72) Inventors:
  • SEPP-LORENZINO, Laura
    Cambridge, MA 02142 (US)
  • JADHAV, Vasant
    Cambridge, MA 02142 (US)
  • BROWN, Duncan
    Berkeley, CA 94708 (US)
  • TADIN-STRAPPS, Marija
    Boston, MA 02115 (US)
  • KHAN, Tayeba
    Lexington, MA 02421 (US)
  • STRAPPS, Walter, Richard
    Dedham, MA 02026 (US)

(74) Representative: Vossius & Partner Patentanwälte Rechtsanwälte mbB 
Siebertstrasse 3
81675 München
81675 München (DE)

   


(54) SYSTEMIC DELIVERY OF MYOSTATIN SHORT INTERFERING NUCLEIC ACIDS (SINA) CONJUGATED TO A LIPOPHILIC MOIETY