(19)

(11)

EP 3 068 930 A2

(12)

(88) Date of publication A3: 14.01.2016 (43) Date of publication: 21.09.2016 Bulletin 2016/38 (21) Application number: 14862279.8 (22) Date of filing: 12.11.2014

(51) International Patent Classification (IPC):  C40B 30/08(2006.01) C12N 9/12(2006.01) C40B 20/00(2006.01) (86) International application number: PCT/US2014/065173 (87) International publication number: WO 2015/073509 (21.05.2015 Gazette 2015/20)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 12.11.2013 US 201361902877 P 17.03.2014 US 201461954046 P (71) Applicant: Dana-Farber Cancer Institute, Inc. Boston, MA 02115-5450 (US)	(72) Inventors: ZHAO, Jean Brookline, MA 02446 (US) WANG, Yubao Newton, MA 02466 (US) (74) Representative: Helbig, Christian  Wagner + Helbig Patentanwälte Pfarrstrasse 14 80538 München 80538 München (DE)