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EP 3 074 044 A2

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(88) Date of publication A3: 13.08.2015 (43) Date of publication: 05.10.2016 Bulletin 2016/40 (21) Application number: 14827537.3 (22) Date of filing: 27.11.2014

(51) International Patent Classification (IPC):  A61K 45/06(2006.01) A61K 31/12(2006.01) A61K 31/216(2006.01) A61K 31/352(2006.01) A61K 31/4709(2006.01) A61K 31/7028(2006.01) A61K 31/7034(2006.01) A61P 35/00(2006.01) A61K 31/05(2006.01) A61K 31/155(2006.01) A61K 31/235(2006.01) A61K 31/353(2006.01) A61K 31/7024(2006.01) A61K 31/7032(2006.01) A61K 31/7048(2006.01) A61P 35/04(2006.01) (86) International application number: PCT/IB2014/066404 (87) International publication number: WO 2015/079413 (04.06.2015 Gazette 2015/22)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 28.11.2013 US 201361910086 P 28.11.2013 WO PCT/IL2013/050986 (71) Applicant: Yeda Research and Development Co., Ltd. 7610002 Rehovot (IL)	(72) Inventors: YARDEN, Yosef 7630921 Rehovot (IL) BEN-CHETRIT, Nir 7610002 Rehovot (IL) (74) Representative: Dennemeyer & Associates S.A.  Postfach 70 04 25 81304 München 81304 München (DE)