(19)
(11) EP 3 083 057 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
21.08.2019 Bulletin 2019/34

(45) Mention of the grant of the patent:
10.07.2019 Bulletin 2019/28

(21) Application number: 14885808.7

(22) Date of filing: 19.12.2014
(51) International Patent Classification (IPC): 
B01L 3/00(2006.01)
C12M 3/00(2006.01)
(86) International application number:
PCT/US2014/071570
(87) International publication number:
WO 2015/138032 (17.09.2015 Gazette 2015/37)

(54)

ORGANOMIMETIC DEVICES AND METHODS OF USE AND MANUFACTURING THEREOF

ORGANOMIMETISCHE VORRICHTUNGEN UND VERFAHREN ZUR VERWENDUNG UND HERSTELLUNG DAVON

DISPOSITIFS ORGANO-MIMÉTIQUES ET LEURS PROCÉDÉS DE FABRICATION


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 20.12.2013 US 201361919181 P

(43) Date of publication of application:
26.10.2016 Bulletin 2016/43

(60) Divisional application:
19184426.5

(73) Proprietor: President and Fellows of Harvard College
Cambridge, MA 02138 (US)

(72) Inventors:
  • FERNANDEZ-ALCON, Jose
    Cambridge, Massachusetts 02139 (US)
  • WEN, Norman
    Newton, Massachusetts 02461 (US)
  • NOVAK, Richard
    Cambridge, Massachusetts 02138 (US)
  • INGBER, Donald E.
    Boston, Massachusetts 02118 (US)
  • HAMILTON, Geraldine A.
    Boston, MA 02127 (US)
  • HINOJOSA, Christopher
    Cambridge, Massachusetts 02138 (US)
  • DOMANSKY, Karel
    Charlestown, Massachusetts 02129 (US)
  • LEVNER, Daniel
    Brookline, MA 02446 (US)
  • THOMPSON, II Guy
    Watertown, MA 02472 (US)
  • HAJIPOURAN BENAM, Kambez
    Cambridge, Massachusetts 02138 (US)
  • VILLENAVE, Remi
    Boston, MA 02210 (US)
  • UMUNDUM, Thomas
    A-5302 Henndorf (AT)
  • PARIS, Alfred
    A-5020 Salzburg (AT)
  • BAUER, Georg
    A-5020 Salzburg (AT)

(74) Representative: Haseltine Lake Kempner LLP 
Redcliff Quay 120 Redcliff Street
Bristol BS1 6HU
Bristol BS1 6HU (GB)


(56) References cited: : 
WO-A1-2013/085909
WO-A2-2012/118799
US-A1- 2011 250 585
WO-A1-2013/086486
US-A1- 2002 166 585
   
  • D. HUH ET AL: "From 3D cell culture to organs-on-chips", TRENDS IN CELL BIOLOGY (ELSEVIER LTD), vol. 21, no. 12, 1 December 2011 (2011-12-01), pages 745-754, XP028120988, New York NY USA ISSN: 0962-8924, DOI: 10.1016/J.TCB.2011.09.005 [retrieved on 2011-09-23]
  • WYSS INSTITUTE: "Wyss Institute Models a Human Disease in an Organ-on-a-Chip", WYSS INSTITUTE OF HARVARD COLLEGE NEWS, 7 November 2012 (2012-11-07), pages 1-8, XP055312818, Boston MA USA
  • B. SANGEETA & D.E. INGBER: "Microfluidic organs-on-chips", NATURE BIOTECHNOLOGY (NATURE AMERICA), vol. 32, no. 8, 5 August 2014 (2014-08-05) , pages 760-772, XP002761628, New York NY USA
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).