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EP 3 083 604 A1

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(43) Date of publication: 26.10.2016 Bulletin 2016/43 (21) Application number: 14815839.7 (22) Date of filing: 19.12.2014

(51) International Patent Classification (IPC):  C07D 403/12(2006.01) A61K 31/4427(2006.01) A61K 31/506(2006.01) C07D 213/75(2006.01) C07D 401/02(2006.01) C07D 405/12(2006.01) C07D 413/12(2006.01) A61K 31/44(2006.01) A61K 31/505(2006.01) C07D 213/74(2006.01) C07F 9/53(2006.01) C07D 401/12(2006.01) C07D 239/47(2006.01) (86) International application number: PCT/GB2014/053781 (87) International publication number: WO 2015/092423 (25.06.2015 Gazette 2015/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 20.12.2013 GB 201322672 17.09.2014 GB 201416430 (71) Applicants: Respivert Limited High Wycombe, Buckinghamshire HP12 4EG (GB) Topivert Pharma Limited London WC2R 1BH (GB)

(72) Inventors: FYFE, Matthew Colin Thor London Greater London SW7 2BP (GB) THOM, Stephen Malcolm Nottingham Nottinghamshire NG1 1GF (GB) BAKER, Thomas Matthew Nottingham Nottinghamshire NG1 1GF (GB) HARBOTTLE, Gareth William Nottingham Nottinghamshire NG1 1GF (GB) HASIMBEGOVIC, Vedran Nottingham Nottinghamshire NG1 1GF (GB) RIGBY, Aaron Nottingham Nottinghamshire NG1 1GF (GB) (74) Representative: Beacham, Annabel Rose  Dehns St Bride's House 10 Salisbury Square London EC4Y 8JD London EC4Y 8JD (GB)