BILIRUBIN PARTICLES AND THEIR PREPARATION FOR USE IN THERAPY

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EP 3 088 353 B8

(12)	CORRECTED EUROPEAN PATENT SPECIFICATION
	Note: Bibliography reflects the latest situation

(15)	Correction information:
	Corrected version no 1 (W1 B1)

(48)	Corrigendum issued on:
	08.04.2020 Bulletin 2020/15

(45)	Mention of the grant of the patent:
	18.12.2019 Bulletin 2019/51

(21)	Application number: 14875349.4

(22)	Date of filing: 26.12.2014

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International Patent Classification (IPC):

A61K 47/60^(2017.01)
A61K 31/704^(2006.01)
B82Y 5/00^(2011.01)
A61P 29/00^(2006.01)

A61K 47/69^(2017.01)
B82B 1/00^(2006.01)
A61P 35/00^(2006.01)

(86)	International application number:
	PCT/KR2014/012912

(87)	International publication number:
	WO 2015/099492 (02.07.2015 Gazette 2015/26)

(54)	BILIRUBIN PARTICLES AND THEIR PREPARATION FOR USE IN THERAPY BILIRUBINPARTIKEL UND DEREN HERSTELLUNG ZUR VERWENDUNG BEI DER THERAPIE PARTICULES DE BILIRUBINE ET LEUR PRÉPARATION POUR UTILISATION EN THÉRAPIE

(84)	Designated Contracting States:
	AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

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Priority:

27.12.2013 KR 20130165718

(43)	Date of publication of application:
	02.11.2016 Bulletin 2016/44

(73)	Proprietor: Bilix Co., Ltd.
	Seoul 06241 (KR)

(72)	Inventors:
	JON, Sang Yong Daejeon 305-340 (KR) LEE, Yong Hyun Daejeon 305-701 (KR)

(74)	Representative: Plougmann Vingtoft a/s
	Strandvejen 70 2900 Hellerup 2900 Hellerup (DK)

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References cited: :

WO-A1-2008/130180
US-A1- 2007 015 816
US-A1- 2013 345 614

US-A1- 2004 013 717
US-A1- 2011 022 129
US-B1- 6 916 488

STEFAN E. BOIADJIEV ET AL: "pKa and Aggregation of Bilirubin: Titrimetric and Ultracentrifugation Studies on Water-Soluble Pegylated Conjugates of Bilirubin and Fatty Acids", BIOCHEMISTRY, vol. 43, no. 49, 18 November 2004 (2004-11-18), pages 15617-15632, XP055317791, US ISSN: 0006-2960, DOI: 10.1021/bi0481491
YONGHYUN LEE ET AL: "Bilirubin Nanoparticles as a Nanomedicine for Anti-inflammation Therapy", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 55, no. 26, 4 May 2016 (2016-05-04), pages 7460-7463, XP055317213, DE ISSN: 1433-7851, DOI: 10.1002/anie.201602525
YONGHYUN LEE ET AL: "Multistimuli-Responsive Bilirubin Nanoparticles for Anticancer Therapy", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 55, no. 36, 3 August 2016 (2016-08-03), pages 10676-10680, XP055317220, DE ISSN: 1433-7851, DOI: 10.1002/anie.201604858
PASHKOVSKAYA, A. ET AL.: 'Light-Triggered Liposomal Release: Membrane Permeabilization by Photodynamic Action' LANGMUIR vol. 26, no. 8, 10 December 2009, pages 5726 - 5733, XP055292129
R Nagarajan: "Chapter 1 Amphiphilic Surfactants and Amphiphilic Polymers: Principles of Molecular Assembly" In: "Amphiphiles: Molecular Assembly and Applications", 1 January 2011 (2011-01-01) pages 1-22, DOI: 10.1021/bk-2011-1070,

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