(19)
(11) EP 3 110 942 A2

(12)

(88) Date of publication A3:
28.01.2016

(43) Date of publication:
04.01.2017 Bulletin 2017/01

(21) Application number: 15755609.3

(22) Date of filing: 25.02.2015
(51) International Patent Classification (IPC): 
C12N 1/12(2006.01)
C12N 1/20(2006.01)
(86) International application number:
PCT/US2015/017559
(87) International publication number:
WO 2015/130810 (03.09.2015 Gazette 2015/35)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME

(30) Priority: 25.02.2014 US 201414189008
02.05.2014 US 201414268436
06.11.2014 US 201462076411 P

(71) Applicants:
  • Advaxis, Inc.
    Princeton, NJ 08540 (US)
  • The Trustees of The University of Pennsylvania
    Philadelphia, PA 19104-6283 (US)

(72) Inventors:
  • SHAHABI, Vafa
    Valley Forge, Pennsylvania 19481 (US)
  • WALLECHA, Anu
    Yardley, Pennsylvania 19067 (US)
  • MACIAG, Paulo C.
    Long Grove, Illinois 60047 (US)
  • PATERSON, Yvonne
    Philadelphia, Pennsylvania 19102 (US)
  • MASON, Nicola
    Philadelphia, Pennsylvania 19107 (US)
  • SEAVEY, Matthew
    Secane, Pennsylvania 19018 (US)

(74) Representative: Bentham, Andrew 
J A Kemp 14 South Square Gray's Inn
London WC1R 5JJ
London WC1R 5JJ (GB)

   


(54) COMPOSITIONS AND METHODS FOR THE TREATMENT OF HER2/NEU OVER-EXPRESSING TUMORS