(19)
(11) EP 3 113 794 A2

(12)

(88) Date of publication A3:
29.10.2015

(43) Date of publication:
11.01.2017 Bulletin 2017/02

(21) Application number: 15758226.3

(22) Date of filing: 05.03.2015
(51) International Patent Classification (IPC): 
A61K 39/02(2006.01)
(86) International application number:
PCT/US2015/018915
(87) International publication number:
WO 2015/134722 (11.09.2015 Gazette 2015/36)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
MA

(30) Priority: 05.03.2014 US 201461948453 P

(71) Applicants:
  • Advaxis, Inc.
    Princeton, NJ 08540 (US)
  • National Institutes of Health, as represented by the Secretary, Department of Health and Human Services of the Government
    Bethesda, Maryland (US)

(72) Inventors:
  • PETIT, Robert
    Newtown (Wrightstown), Pennsylvania 18940 (US)
  • WALLECHA, Anu
    Yardley, Pennsylvania 19067 (US)
  • CHEN, Zhisong
    Potomac, Maryland 20854 (US)
  • BERZOFSKY, Jay A.
    Bethesda, Maryland 20814 (US)
  • KHLEIF, Samir
    Silver Springs, Maryland 20906 (US)

(74) Representative: Bentham, Andrew 
J A Kemp 14 South Square Gray's Inn
London WC1R 5JJ
London WC1R 5JJ (GB)

   


(54) METHODS AND COMPOSITIONS FOR INCREASING A T-EFFECTOR CELL TO REGULATORY T CELL RATIO