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EP 3 129 027 A1

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(43) Date of publication: 15.02.2017 Bulletin 2017/07 (21) Application number: 15829650.9 (22) Date of filing: 14.02.2015

(51) International Patent Classification (IPC):  A61K 31/535(2006.01) A61P 25/14(2006.01) C07C 251/28(2006.01) A61K 31/165(2006.01) A61P 25/28(2006.01) C07D 265/06(2006.01) (86) International application number: PCT/IB2015/000144 (87) International publication number: WO 2016/020732 (11.02.2016 Gazette 2016/06)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 05.08.2014 US 201462033401 P (71) Applicants: University of British Columbia Vancouver, British Columbia V6T 1Z4 (CA) Universität Hamburg 20148 Hamburg (DE)	(72) Inventors: KHANKISCHPUR, Medhi, Mike 20259 Hamburg (DE) PETINA, Olga 52351 Deuren (DE) GEFFKEN, Detlef 20253 Hamburg (DE) ERNHOEFER, Dagmar Vancouver, BC V5W 1L8 (CA) HAYDEN, Michael Vancouver, BC V6R 1W9 (CA) (74) Representative: Jones, Nicholas Andrew  Withers & Rogers LLP 4 More London Riverside London, SE1 2AU London, SE1 2AU (GB)