(19)
(11) EP 3 129 392 A1

(12)

(43) Date of publication:
15.02.2017 Bulletin 2017/07

(21) Application number: 15718402.9

(22) Date of filing: 09.04.2015
(51) International Patent Classification (IPC): 
C07J 63/00(2006.01)
A61K 31/56(2006.01)
C07F 5/02(2006.01)
 A61K 31/58(2006.01)
A61P 31/18(2006.01)
C07C 309/65(2006.01)
(86) International application number:
PCT/US2015/025029
(87) International publication number:
WO 2015/157483 (15.10.2015 Gazette 2015/41)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
MA

(30) Priority: 11.04.2014 US 201461978306 P

(71) Applicant: VIIV Healthcare UK(No.4) Limited
Brentford, TW8 9GS (GB)

(72) Inventors:
  • SIT, Sing-Yuen
    Wallingford, Connecticut 06492 (US)
  • CHEN, Yan
    Wallingford, Connecticut 06492 (US)
  • CHEN, Jie
    Wallingford, Connecticut 06492 (US)
  • SWIDORSKI, Jacob
    Wallingford, Connecticut 06492 (US)
  • VENABLES, Brian Lee
    Wallingford, Connecticut 06492 (US)
  • SIN, Ny
    Wallingford, Connecticut 06492 (US)
  • MEANWELL, Nicholas A.
    Wallingford, Connecticut 06492 (US)
  • REGUEIRO-REN, Alicia
    Wallingford, Connecticut 06492 (US)
  • HARTZ, Richard A.
    Wallingford, Connecticut 06492 (US)
  • XU, Li
    Wallingford, Connecticut 06492 (US)
  • LIU, Zheng
    Wallingford, Connecticut 06492 (US)

(74) Representative: Learoyd, Stephanie Anne 
GlaxoSmithKline Global Patents (CN925.1) 980 Great West Road
Brentford, Middlesex TW8 9GS
Brentford, Middlesex TW8 9GS (GB)

   


(54) TRITERPENOIDS WITH HIV MATURATION INHIBITORY ACTIVITY, SUBSTITUTED IN POSITION 3 BY A NON-AROMATIC RING CARRYING A HALOALKYL SUBSTITUENT