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<ep-patent-document id="EP15718988B8W1" file="EP15718988W1B8.xml" lang="en" country="EP" doc-number="3132036" kind="B8" correction-code="W1" date-publ="20200422" status="c" dtd-version="ep-patent-document-v1-5">
<SDOBI lang="en"><B000><eptags><B001EP>ATBECHDEDKESFR..GRITLILUNLSEMCPTIESILTLVFIROMKCYALTRBGCZEEHUPLSK..HRIS..MTNORS..SM..................</B001EP><B003EP>*</B003EP><B005EP>J</B005EP><B007EP>BDM Ver 1.7.2 (20 November 2019) -  2999001/0</B007EP></eptags></B000><B100><B110>3132036</B110><B120><B121>CORRECTED EUROPEAN PATENT SPECIFICATION</B121></B120><B130>B8</B130><B132EP>B1</B132EP><B140><date>20200422</date></B140><B150><B151>W1</B151><B153>73</B153><B155><B1551>de</B1551><B1552>Bibliographie</B1552><B1551>en</B1551><B1552>Bibliography</B1552><B1551>fr</B1551><B1552>Bibliographie</B1552></B155></B150><B190>EP</B190></B100><B200><B210>15718988.7</B210><B220><date>20150416</date></B220><B240><B241><date>20161014</date></B241><B242><date>20170914</date></B242></B240><B250>en</B250><B251EP>en</B251EP><B260>en</B260></B200><B300><B310>201406970</B310><B320><date>20140417</date></B320><B330><ctry>GB</ctry></B330></B300><B400><B405><date>20200422</date><bnum>202017</bnum></B405><B430><date>20170222</date><bnum>201708</bnum></B430><B450><date>20200115</date><bnum>202003</bnum></B450><B452EP><date>20190730</date></B452EP><B480><date>20200422</date><bnum>202017</bnum></B480></B400><B500><B510EP><classification-ipcr sequence="1"><text>C12N  15/10        20060101AFI20151027BHEP        </text></classification-ipcr><classification-ipcr sequence="2"><text>C12N  15/74        20060101ALI20151027BHEP        </text></classification-ipcr><classification-ipcr sequence="3"><text>C12N  15/90        20060101ALI20151027BHEP        </text></classification-ipcr></B510EP><B540><B541>de</B541><B542>GEZIELTE MUTATIONEN</B542><B541>en</B541><B542>TARGETED MUTATIONS</B542><B541>fr</B541><B542>MUTATIONS CIBLEES</B542></B540><B560><B561><text>WO-A1-2008/040387</text></B561><B561><text>WO-A1-2014/143381</text></B561><B561><text>WO-A1-2014/191518</text></B561><B561><text>WO-A1-2015/040402</text></B561><B561><text>WO-A2-2007/148091</text></B561><B561><text>WO-A2-2009/101400</text></B561><B562><text>JIANG ET AL.: "RNA-guided editing of bacterial genomes using CRISPR-Cas systems", NATURE BIOTECHNOLOGY, vol. 31, 2013, pages 233-239, XP002699849, cited in the application</text></B562><B562><text>WANG YI ET AL: "Markerless chromosomal gene deletion in Clostridium beijerinckii using CRISPR/Cas9 system.", JOURNAL OF BIOTECHNOLOGY, vol. 200, 20 April 2015 (2015-04-20), pages 1-5, XP002741440, ISSN: 1873-4863</text></B562><B562><text>RAN F ANN ET AL: "Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity", CELL, vol. 154, no. 6, 12 September 2013 (2013-09-12), pages 1380-1389, XP028716272, ISSN: 0092-8674, DOI: 10.1016/J.CELL.2013.08.021</text></B562><B562><text>L. 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154AH Brook Drive
Milton Park</str><city>Abingdon
Oxfordshire OX14 4SD</city><ctry>GB</ctry></adr></B721><B721><snm>KRABBEN, Preben</snm><adr><str>9 Marsh Lane</str><city>Didcot
Oxfordshire OX11 8FD</city><ctry>GB</ctry></adr></B721></B720><B730><B731><snm>Biocleave Limited</snm><iid>101846020</iid><irf>489.118730/04</irf><adr><str>154AH Brook Drive 
Milton Park</str><city>Abingdon, Oxfordshire OX14 4SD</city><ctry>GB</ctry></adr></B731></B730><B740><B741><snm>Dehns</snm><iid>101728904</iid><adr><str>St. Bride's House 
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