(19)
(11) EP 3 137 107 A1

(12)

(43) Date of publication:
08.03.2017 Bulletin 2017/10

(21) Application number: 15786740.9

(22) Date of filing: 02.04.2015
(51) International Patent Classification (IPC): 
A61K 39/02(2006.01)
A61K 39/38(2006.01)
C12P 21/08(2006.01)
C12N 5/16(2006.01)
 A61K 39/00(2006.01)
C12P 21/04(2006.01)
C12N 5/07(2010.01)
(86) International application number:
PCT/US2015/024048
(87) International publication number:
WO 2015/167748 (05.11.2015 Gazette 2015/44)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
MA

(30) Priority: 02.05.2014 US 201414268436
06.11.2014 US 201462076411 P
25.02.2015 WO PCT/US2015/017559
26.03.2015 US 201514669629

(71) Applicant: The Trustees of The University of Pennsylvania
Philadelphia, PA 19104-6283 (US)

(72) Inventors:
  • PATERSON, Yvonne
    Philadelphia, Pennsylvania 19102 (US)
  • MASON, Nicola
    Philadelphia, Pennsylvania 19107 (US)

(74) Representative: Pearl Cohen Zedek Latzer Baratz UK LLP 
16 Upper Woburn Place
London WC1H 0BS
London WC1H 0BS (GB)

   


(54) COMBINATION IMMUNO THERAPY AND RADIOTHERAPY FOR THE TREATMENT OF HER-2-POSITIVE CANCERS