(19)
(11) EP 3 137 110 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
10.08.2022 Bulletin 2022/32

(45) Mention of the grant of the patent:
06.07.2022 Bulletin 2022/27

(21) Application number: 15786559.3

(22) Date of filing: 04.05.2015
(51) International Patent Classification (IPC): 
A61K 39/395(2006.01)
C07K 16/32(2006.01)
A61P 25/00(2006.01)
A61K 39/00(2006.01)
(52) Cooperative Patent Classification (CPC):
A61K 2039/505; C07K 2317/24; C07K 2317/76; C07K 16/32; A61P 25/00
(86) International application number:
PCT/CA2015/050500
(87) International publication number:
WO 2015/164984 (05.11.2015 Gazette 2015/44)

(54)

ERBB2 SIGNALING AND NERVE REGENERATION

ERBB2-SIGNALISIERUNG UND NERVENREGENERATION

SIGNALISATION ERBB2 ET RÉGÉNÉRATION NERVEUSE


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 02.05.2014 US 201461987692 P

(43) Date of publication of application:
08.03.2017 Bulletin 2017/10

(73) Proprietor: The Hospital For Sick Children
Toronto, Ontario M5G 1X8 (CA)

(72) Inventors:
  • HENDRY, James M.
    Kingston, ON K7M6R4 (CA)
  • PLACHETA, Eva
    A-1190 Vienna (AT)
  • GORDON, Tessa
    Toronto, Ontario M5M 1R9 (CA)
  • BORSCHEL, Gregory H.
    Toronto, Ontario M5M 2G8 (CA)

(74) Representative: Lecomte & Partners 
76-78, rue de Merl
2146 Luxembourg
2146 Luxembourg (LU)


(56) References cited: : 
   
  • PLACHETA EVA ET AL: "The ErbB2 inhibitor Herceptin (Trastuzumab) promotes axonal outgrowth four weeks after acute nerve transection and repair", NEUROSCIENCE LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 582, 8 September 2014 (2014-09-08), pages 81-86, XP029049218, ISSN: 0304-3940, DOI: 10.1016/J.NEULET.2014.09.006
  • J. MICHAEL HENDRY ET AL: "ErbB2 blockade with Herceptin (trastuzumab) enhances peripheral nerve regeneration after repair of acute or chronic peripheral nerve injury : Herceptin and Regeneration", ANNALS OF NEUROLOGY., vol. 80, no. 1, 6 June 2016 (2016-06-06), pages 112-126, XP055409406, BOSTON, US ISSN: 0364-5134, DOI: 10.1002/ana.24688
  • HUNG-MING CHANG ET AL: "Neuregulin Facilitates Nerve Regeneration by Speeding Schwann Cell Migration via ErbB2/3-Dependent FAK Pathway", PLOS ONE, vol. 8, no. 1, 2 January 2013 (2013-01-02) , page e53444, XP055409408, DOI: 10.1371/journal.pone.0053444
  • GIULIA RONCHI ET AL: "ErbB2 Receptor Over-Expression Improves Post-Traumatic Peripheral Nerve Regeneration in Adult Mice", PLOS ONE, vol. 8, no. 2, 21 February 2013 (2013-02-21), page e56282, XP055409534, DOI: 10.1371/journal.pone.0056282
  • FLORENCE R FRICKER ET AL: "The role of neuregulin-1 in the response to nerve injury", FUTURE NEUROLOGY, vol. 6, no. 6, 1 November 2011 (2011-11-01), pages 809-822, XP055409538, GB ISSN: 1479-6708, DOI: 10.2217/fnl.11.45
  • BASELGA, J. ET AL.: 'Mechanism of action of Trastuzumab and scientific update' SEMINARS IN ONCOLOGY vol. 28, October 2001, pages 4 - 11, XP008185063
  • PLACHETA, E. ET AL.: 'The ErbB2 inhibitor Herceptin (Trastuzumab) promotes axonal outgrowth four weeks after acute nerve transection and repair' NEUROSCIENCE LETTERS vol. 582, October 2014, ISSN 1872-7972 pages 81 - 86, XP029049218
  • RAIMONDO, S. ET AL.: 'Schwann cell behaviour after nerve repair by means of tissue-engineered muscle-vein combined guides' J. COMPARATIVE NEUROLOGY vol. 489, August 2005, ISSN 0021-9967 pages 249 - 259, XP055233967
  • ATANASOSKI, S. ET AL.: 'ErbB2 signaling in Schwann cells is mostly dispensable for maintenance of myelinated peripheral nerves and proliferation of adult Schwann cells after injury' J. NEUROSCIENCE vol. 26, February 2006, ISSN 1529-2401 pages 2124 - 2131, XP055233969
   
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