ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESILTLVFIROMKCYALTRBGCZEEHUPLSK..HRIS..MTNORS..SM..................*JBDM Ver 2.0.16 (1th of February 2022) - 2999001/03137110CORRECTED EUROPEAN PATENT SPECIFICATIONB8B120220810W172deBibliographieenBibliographyfrBibliographieEP15786559.3201505042016111820181001enenen201461987692 P20140502US2022081020223220170308201710202207062022272022012120220810202232A61K 39/395 20060101AFI20170929BHEP A61P 25/00 20060101ALI20170929BHEP C07K 16/32 20060101ALI20170929BHEP A61K 39/00 20060101ALI20170929BHEP A61K2039/505 20130101 LA20170303BHEP C07K2317/24 20130101 LA20160121BHEP C07K2317/76 20130101 LA20170303BHEP C07K 16/32 20130101 FI20170303BHEP A61P 25/00 20180101 LI20200320BHEP deERBB2-SIGNALISIERUNG UND NERVENREGENERATIONenERBB2 SIGNALING AND NERVE REGENERATIONfrSIGNALISATION ERBB2 ET RÉGÉNÉRATION NERVEUSEPLACHETA EVA ET AL: "The ErbB2 inhibitor Herceptin (Trastuzumab) promotes axonal outgrowth four weeks after acute nerve transection and repair", NEUROSCIENCE LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 582, 8 September 2014 (2014-09-08), pages 81-86, XP029049218, ISSN: 0304-3940, DOI: 10.1016/J.NEULET.2014.09.006J. MICHAEL HENDRY ET AL: "ErbB2 blockade with Herceptin (trastuzumab) enhances peripheral nerve regeneration after repair of acute or chronic peripheral nerve injury : Herceptin and Regeneration", ANNALS OF NEUROLOGY., vol. 80, no. 1, 6 June 2016 (2016-06-06), pages 112-126, XP055409406, BOSTON, US ISSN: 0364-5134, DOI: 10.1002/ana.24688HUNG-MING CHANG ET AL: "Neuregulin Facilitates Nerve Regeneration by Speeding Schwann Cell Migration via ErbB2/3-Dependent FAK Pathway", PLOS ONE, vol. 8, no. 1, 2 January 2013 (2013-01-02) , page e53444, XP055409408, DOI: 10.1371/journal.pone.0053444GIULIA RONCHI ET AL: "ErbB2 Receptor Over-Expression Improves Post-Traumatic Peripheral Nerve Regeneration in Adult Mice", PLOS ONE, vol. 8, no. 2, 21 February 2013 (2013-02-21), page e56282, XP055409534, DOI: 10.1371/journal.pone.0056282FLORENCE R FRICKER ET AL: "The role of neuregulin-1 in the response to nerve injury", FUTURE NEUROLOGY, vol. 6, no. 6, 1 November 2011 (2011-11-01), pages 809-822, XP055409538, GB ISSN: 1479-6708, DOI: 10.2217/fnl.11.45BASELGA, J. ET AL.: 'Mechanism of action of Trastuzumab and scientific update' SEMINARS IN ONCOLOGY vol. 28, October 2001, pages 4 - 11, XP008185063PLACHETA, E. ET AL.: 'The ErbB2 inhibitor Herceptin (Trastuzumab) promotes axonal outgrowth four weeks after acute nerve transection and repair' NEUROSCIENCE LETTERS vol. 582, October 2014, ISSN 1872-7972 pages 81 - 86, XP029049218RAIMONDO, S. ET AL.: 'Schwann cell behaviour after nerve repair by means of tissue-engineered muscle-vein combined guides' J. COMPARATIVE NEUROLOGY vol. 489, August 2005, ISSN 0021-9967 pages 249 - 259, XP055233967ATANASOSKI, S. ET AL.: 'ErbB2 signaling in Schwann cells is mostly dispensable for maintenance of myelinated peripheral nerves and proliferation of adult Schwann cells after injury' J. NEUROSCIENCE vol. 26, February 2006, ISSN 1529-2401 pages 2124 - 2131, XP05523396920171006HENDRY, James M.59 Lakeshore BlvdKingston, ON K7M6R4CAPLACHETA, EvaWindhabergasse 12/3A-1190 ViennaATGORDON, Tessa520 Brookdale AvenueToronto, Ontario M5M 1R9CABORSCHEL, Gregory H.541 Orchard GroveToronto, Ontario M5M 2G8CAThe Hospital For Sick Children101952678PT04972EPIndustry Partnerships & Commercialization 555 University AvenueToronto, Ontario M5G 1X8CALecomte & Partners10127844176-78, rue de Merl2146 LuxembourgLUALATBEBGCHCYCZDEDKEEESFIFRGBGRHRHUIEISITLILTLULVMCMKMTNLNOPLPTRORSSESISKSMTRCA201505050020150504enWO201516498420151105201544