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(11)

EP 3 140 274 A1

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(43) Date of publication: 15.03.2017 Bulletin 2017/11 (21) Application number: 15788940.3 (22) Date of filing: 08.05.2015

(51) International Patent Classification (IPC):  C07C 50/10(2006.01) C07C 50/12(2006.01) (86) International application number: PCT/US2015/029977 (87) International publication number: WO 2015/172076 (12.11.2015 Gazette 2015/45)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA (30) Priority: 09.05.2014 US 201461990905 P 06.08.2014 US 201462033938 P (71) Applicant: Sloan-kettering Institute For Cancer Research New York, NY 10065 (US)	(72) Inventors: LUO, Minkui New York, NY 10075 (US) SANCHEZ, Glorymar, Ibanez Corona, NY 11368 (US) BLUM, Gil, Joseph New York, NY 10065 (US) YANG, Li New York, NY 10022 (US) PITTELLA SILVA, Fabio New York, NY 10021 (US) (74) Representative: Crooks, Elizabeth Caroline et al Kilburn & Strode LLP 20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)