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(11)

EP 3 143 133 A1

(12)

(43) Date of publication: 22.03.2017 Bulletin 2017/12 (21) Application number: 15726393.0 (22) Date of filing: 18.05.2015

(51) International Patent Classification (IPC):  C12N 5/0783(2010.01) C12N 5/077(2010.01) A61K 35/12(2015.01) C12N 5/0775(2010.01) (86) International application number: PCT/PT2015/000022 (87) International publication number: WO 2015/174871 (19.11.2015 Gazette 2015/46)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA (30) Priority: 16.05.2014 GB 201408753 (71) Applicant: Stemmatters, Biotecnologia e Medicina Regenerativa, S.A. 4805-017 Barco GMR (PT)

(72) Inventors: SOUSA, Rui Pedro Romero Amandi de 4805-017 Barco GMR (PT) CORREIA, Cristina 4805-017 Barco GMR (PT) FRIAS, Ana Margarida Garcez Luis de 4805-017 Barco GMR (PT) MOREIRA, Elsa Fátima André de Sousa 4805-017 Barco GMR (PT) COSTA, Dulce Paula da Silva dos Santos 4805-017 Barco GMR (PT) GREGÓRIO, Maria Inês Silva 4805-017 Barco GMR (PT) REIS, Rui Luís Gonçalves dos 4805-017 Barco GMR (PT) (74) Representative: Patentree, Lda.  Edificio Net Rua de Salazares, 842 4149-002 Porto 4149-002 Porto (PT)