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(11)

EP 3 148 983 A1

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(43) Date of publication: 05.04.2017 Bulletin 2017/14 (21) Application number: 15729288.9 (22) Date of filing: 26.05.2015

(51) International Patent Classification (IPC):  C07D 401/06(2006.01) C07D 405/06(2006.01) C07D 239/62(2006.01) A61P 9/00(2006.01) C07D 403/06(2006.01) C07D 409/06(2006.01) A61K 31/515(2006.01) (86) International application number: PCT/US2015/032493 (87) International publication number: WO 2015/183838 (03.12.2015 Gazette 2015/48)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA (30) Priority: 27.05.2014 US 201462003353 P (71) Applicant: The Johns Hopkins University Baltimore, MD 21218 (US)	(72) Inventors: GUTHRIE, Daryl A. Baltimore, MD 21211 (US) TOSCANO, John P. Glen Arm, MD 21057 (US) (74) Representative: Beacham, Annabel Rose  Dehns St Bride's House 10 Salisbury Square London EC4Y 8JD London EC4Y 8JD (GB)