(19)
(11) EP 3 150 593 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
21.08.2019 Bulletin 2019/34

(45) Mention of the grant of the patent:
24.04.2019 Bulletin 2019/17

(21) Application number: 16197611.3

(22) Date of filing: 28.11.2008
(51) International Patent Classification (IPC): 
C07D 403/12(2006.01)
C07D 403/06(2006.01)
C07D 239/94(2006.01)
A61K 31/517(2006.01)
A61K 31/52(2006.01)
A61K 31/7076(2006.01)
C07D 471/04(2006.01)
C07D 487/04(2006.01)
C07H 19/16(2006.01)
C07D 403/04(2006.01)
C07D 239/42(2006.01)
A61K 45/06(2006.01)
A61K 31/519(2006.01)
A61K 31/5377(2006.01)
C07D 417/04(2006.01)
C07D 473/34(2006.01)
C07D 495/04(2006.01)

(54)

SMALL MOLECULE MYRISTATE INHIBITORS OF BCR-ABL AND METHODS OF USE

KLEINE VERBINDUNGEN ALS MYRISTATHEMMER VON BCR-ABL UND VERWENDUNGSVERFAHREN

PETITE MOLÉCULES EN TANT QUE INHIBITEURS DE MYRISTATE DE BCR-ABL ET PROCÉDÉS D'UTILISATION


(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR

(30) Priority: 28.11.2007 US 4462 P

(43) Date of publication of application:
05.04.2017 Bulletin 2017/14

(60) Divisional application:
19170210.9

(62) Application number of the earlier application in accordance with Art. 76 EPC:
08857261.5 / 2222162

(73) Proprietors:
  • Dana Farber Cancer Institute, Inc.
    Boston, Massachusetts 02215 (US)
  • The Scripps Research Institute
    La Jolla, CA 92037 (US)

(72) Inventors:
  • GRAY, Nathanael S.
    Boston, MA 02130 (US)
  • ZHANG, Jianming
    Belmont, MA 02478 (US)
  • OKRAM, Barun
    San Marcos, CA 92078 (US)
  • DENG, Xianming
    Xiamen, Fujian (CN)
  • CHANG, Jae Won
    San Diego, CA 92122 (US)

(74) Representative: Harris, Jennifer Lucy et al
Kilburn & Strode LLP Lacon London 84 Theobalds Road
London WC1X 8NL
London WC1X 8NL (GB)


(56) References cited: : 
WO-A1-2005/047288
WO-A2-2005/039486
US-B1- 6 492 383
WO-A2-03/040144
WO-A2-2008/005303
   
       
    Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).