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EP 3 157 943 A1

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(43) Date of publication: 26.04.2017 Bulletin 2017/17 (21) Application number: 15811633.5 (22) Date of filing: 23.06.2015

(51) International Patent Classification (IPC):  C07K 5/103(2006.01) A61P 25/06(2006.01) A61K 38/07(2006.01) (86) International application number: PCT/US2015/037177 (87) International publication number: WO 2015/200322 (30.12.2015 Gazette 2015/52)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA (30) Priority: 23.06.2014 US 201462015727 P 29.01.2015 US 201562109386 P (71) Applicants: Northwestern University Evanston, IL 60208 (US) Naurex, Inc. Evanston, IL 60201 (US)	(72) Inventors: MOSKAL, Joseph R. Evanston, IL 60201 (US) STANTON, Patric Mahopac, NY 10541-3179 (US) (74) Representative: Hoffmann Eitle  Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München 81925 München (DE)