(19)

(11)

EP 3 164 087 A1

(12)

(43) Date of publication: 10.05.2017 Bulletin 2017/19 (21) Application number: 14896951.2 (22) Date of filing: 03.07.2014

(51) International Patent Classification (IPC):  A61B 17/22(2006.01) A61F 2/01(2006.01) A61M 25/01(2006.01) (86) International application number: PCT/US2014/045428 (87) International publication number: WO 2016/003470 (07.01.2016 Gazette 2016/01)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (71) Applicant: The Curators Of The University Of Missouri Columbia, Missouri 65211 (US)	(72) Inventors: ROOD, Kyle St. Peters, Missouri 63376 (US) GOPALDAS, Raja Columbia, Missouri 65203 (US) (74) Representative: Lecomte & Partners  P.O. Box 1623 1016 Luxembourg 1016 Luxembourg (LU)