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(11)

EP 3 164 710 A2

(12)

(88) Date of publication A3: 17.03.2016 (43) Date of publication: 10.05.2017 Bulletin 2017/19 (21) Application number: 15814349.5 (22) Date of filing: 01.07.2015

(51) International Patent Classification (IPC):  G01N 33/50(2006.01) (86) International application number: PCT/US2015/038901 (87) International publication number: WO 2016/004250 (07.01.2016 Gazette 2016/01)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA (30) Priority: 01.07.2014 US 201462019857 P 02.07.2014 US 201462020358 P 17.07.2014 US 201462025953 P 08.09.2014 US 201462047437 P 11.11.2014 US 201462078369 P 17.03.2015 US 201562134245 P 15.05.2015 US 201562162308 P (71) Applicant: Teva Pharmaceutical Industries Ltd. 49131 Petah Tiqva (IL)

(72) Inventors: HAYDEN, Michael 49131 Petach Tikva (IL) TOWFIC, Fadi George Somerville, MA 02144 (US) KOLITZ, Sarah Elisabeth Cambridge, MA 02139 (US) ZESKIND, Benjamin James Cambridge, MA 02142 (US) LADKANI, David 96704 Jerusalem (IL) HASSON, Tal Raanana (IL) HAYARDENY, Liat 69391 Ramat Aviv Tel Aviv (IL) GROSSMAN, Iris 44843 Yakir (IL) (74) Representative: D Young & Co LLP  120 Holborn London EC1N 2DY London EC1N 2DY (GB)