(19)
(11) EP 3 168 309 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
03.06.2020 Bulletin 2020/23

(45) Mention of the grant of the patent:
08.04.2020 Bulletin 2020/15

(21) Application number: 15193966.7

(22) Date of filing: 10.11.2015
(51) International Patent Classification (IPC): 
C12Q 1/6851(2018.01)
 C12Q 1/6883(2018.01)

(54)

DETECTION OF FOETAL CHROMOSOMAL ANEUPLOIDIES USING DNA REGIONS THAT ARE DIFFERENTIALLY METHYLATED BETWEEN THE FOETUS AND THE PREGNANT FEMALE

NACHWEIS VON FÖTALEN CHROMOSOMALEN ANEUPLOIDIEN MITTELS DNA-REGIONEN MIT UNTERSCHIEDLICHER METHYLIERUNG ZWISCHEN DEM FÖTUS UND DER SCHWANGEREN FRAU

DÉTECTION D'ANEUPLOÏDIES CHROMOSOMIQUES FOETALES AU MOYEN DE RÉGIONS D'ADN QUI SONT MÉTHYLÉES DE MANIÈRE DIFFÉRENTIELLE ENTRE LE FOETUS ET LA FEMME ENCEINTE

(84) Designated Contracting States:
BE CH DE DK FI FR GB HU IE LI LU MC NL NO SE

(43) Date of publication of application:
17.05.2017 Bulletin 2017/20

(73) Proprietor: Eurofins LifeCodexx GmbH
78467 Konstanz (DE)

(72) Inventors:
  • WERLER, Steffi
    78467 Konstanz (DE)
  • HOFMANN, Wera
    78467 Konstanz (DE)
  • SACHSE, Matthias
    78467 Konstanz (DE)

(74) Representative: Dörries, Hans Ulrich 
df-mp Dörries Frank-Molnia & Pohlman Patentanwälte Rechtsanwälte PartG mbB Theatinerstrasse 16
80333 München
80333 München (DE)


(56) References cited: : 
WO-A1-03/062441
WO-A2-00/47764
 WO-A1-2012/007783
   
  • SUZANNE SNELLENBERG ET AL: "Development of a multiplex methylation-specific PCR as candidate triage test for women with an HPV-positive cervical scrape", BMC CANCER, BIOMED CENTRAL, LONDON, GB, vol. 12, no. 1, 23 November 2012 (2012-11-23), page 551, XP021128495, ISSN: 1471-2407, DOI: 10.1186/1471-2407-12-551
  • EKATERINA OLKHOV-MITSEL ET AL: "Novel Multiplex MethyLight Protocol for Detection of DNA Methylation in Patient Tissues and Bodily Fluids", SCIENTIFIC REPORTS, vol. 4, 21 March 2014 (2014-03-21), XP055143311, DOI: 10.1038/srep04432
  • THERESA SWIFT-SCANLAN ET AL: "Two-color quantitative multiplex methylation-specific PCR", BIOTECHNIQUES, vol. 40, no. 2, 1 February 2006 (2006-02-01), pages 210-219, XP055143300, ISSN: 0736-6205, DOI: 10.2144/000112097
  • DA EUN LEE ET AL: "Non-Invasive Prenatal Testing of Trisomy 18 by an Epigenetic Marker in First Trimester Maternal Plasma", PLOS ONE, vol. 8, no. 11, 1 November 2013 (2013-11-01), page e78136, XP055258783, DOI: 10.1371/journal.pone.0078136
  • TONG YU K ET AL: "Noninvasive prenatal detection of fetal trisomy 18 by epigenetic allelic ratio analysis in maternal plasma: Theoretical and empirical considerations", CLINICAL CHEMISTRY, AMERICAN ASSOCIATION FOR CLINICAL CHEMISTRY, WASHINGTON, DC, vol. 52, no. 12, 1 December 2006 (2006-12-01), pages 2194-2202, XP002603754, ISSN: 0009-9147, DOI: 10.1373/CLINCHEM.2006.076851 [retrieved on 2006-10-13]
   
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