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EP 3 169 365 A2

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(88) Date of publication A3: 28.01.2016 (43) Date of publication: 24.05.2017 Bulletin 2017/21 (21) Application number: 15723667.0 (22) Date of filing: 07.05.2015

(51) International Patent Classification (IPC):  A61K 45/06(2006.01) A61K 31/166(2006.01) A61K 31/422(2006.01) A61K 31/505(2006.01) A61K 38/43(2006.01) A61K 31/404(2006.01) A61K 31/497(2006.01) A61P 17/04(2006.01) (86) International application number: PCT/EP2015/060019 (87) International publication number: WO 2015/169884 (12.11.2015 Gazette 2015/45)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA (30) Priority: 07.05.2014 US 201461989797 P (71) Applicants: Westfälische Wilhelms-Universität Münster 48149 Münster (DE) The Regents of the University of California Oakland, CA 94607 (US)

(72) Inventors: BUDDENKOTTE, Joerg 33442 Herzebrock-Clarholz (DE) STEINHOFF, Martin Dublin-4 Mt Merrion (IE) (74) Representative: Lorenz & Kopf PartG mbB Patentanwälte, LKGLOBAL  Brienner Straße 11 80333 München 80333 München (DE)