(19)
(11) EP 3 174 534 A1

(12)

(43) Date of publication:
07.06.2017 Bulletin 2017/23

(21) Application number: 15745469.5

(22) Date of filing: 31.07.2015
(51) International Patent Classification (IPC): 
A61K 9/20(2006.01)
A61K 31/485(2006.01)
 A61K 9/28(2006.01)
(86) International application number:
PCT/EP2015/067670
(87) International publication number:
WO 2016/016431 (04.02.2016 Gazette 2016/05)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
MA

(30) Priority: 01.08.2014 EP 14179481
01.10.2014 SI 201400334
16.02.2015 SI 201500032

(71) Applicant: KRKA, d.d., Novo mesto
8000 Novo mesto (SI)

(72) Inventors:
  • MILOZIC, Aleksander
    2251 Ptuj (SI)
  • SMIRNOVA, Elena
    1000 Ljubljana (SI)
  • VRECER, Franc
    8351 Straza pri Novem mestu (SI)
  • RITLOP, Gregor
    1000 Ljubljana (SI)
  • KUKEC, Simon
    1000 Ljubljana (SI)

(74) Representative: Hoffmann Eitle 
Patent- und Rechtsanwälte PartmbB Arabellastraße 30
81925 München
81925 München (DE)

   


(54) PHARMACEUTICAL FORMULATION COMPRISING AN OPIOID AGONIST AND AN OPIOID ANTAGONIST PREPARED BY MELT GRANULATION USING LIPID ESTERS