(19)

(11)

EP 3 183 347 A2

(12)

(88) Date of publication A3: 21.04.2016 (43) Date of publication: 28.06.2017 Bulletin 2017/26 (21) Application number: 15833669.3 (22) Date of filing: 17.10.2015

(51) International Patent Classification (IPC):  C12N 15/113(2010.01) A61K 31/7105(2006.01) A61P 25/08(2006.01) C12N 15/85(2006.01) A61K 48/00(2006.01) (86) International application number: PCT/IB2015/001917 (87) International publication number: WO 2016/027168 (25.02.2016 Gazette 2016/08)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA (30) Priority: 20.08.2014 US 201462039819 P (71) Applicant: Lifesplice Pharma LLC Malvern, PA 19355 (US)	(72) Inventors: TALLENT, Melanie Malvern, PA 19355 (US) LYKENS, Nicole Malvern, PA 19355 (US) LUTZ, Gordon Malvern, PA 19355 (US) (74) Representative: Roques, Sarah Elizabeth  J A Kemp 14 South Square Gray's Inn London WC1R 5JJ London WC1R 5JJ (GB)