(19)
(11) EP 3 190 177 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
27.07.2022 Bulletin 2022/30

(45) Mention of the grant of the patent:
12.01.2022 Bulletin 2022/02

(21) Application number: 16196757.5

(22) Date of filing: 12.05.2011
(51) International Patent Classification (IPC): 
C12N 5/071(2010.01)
C12N 15/113(2010.01)
C12Q 1/68(2018.01)
(52) Cooperative Patent Classification (CPC):
C12N 5/0686; A61P 13/12; A61P 7/06

(54)

BIOACTIVE RENAL CELLS

BIOAKTIVE NIERENZELLEN

CELLULES RÉNALES BIOACTIVES


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME

(30) Priority: 12.05.2010 US 334032 P
11.06.2010 US 353895 P
09.08.2010 US 371888 P
09.08.2010 US 372077 P
24.08.2010 US 376586 P
01.10.2010 US 388765 P
12.11.2010 US 413382 P
12.11.2010 US 412933 P
10.02.2011 US 201161441423 P
07.04.2011 US 201161473111 P

(43) Date of publication of application:
12.07.2017 Bulletin 2017/28

(60) Divisional application:
21212108.1

(62) Application number of the earlier application in accordance with Art. 76 EPC:
11722663.9 / 2569418

(73) Proprietor: ProKidney
Grand Cayman KY1-1104 (KY)

(72) Inventors:
  • Ilagan, Roger, M.
    Burlington, NC 27215 (US)
  • Keller, Russell, W.
    Winston-Salem, NC 27104 (US)
  • Presnell, Sharon, C.
    Lewisville, NC 27023 (US)
  • Choudhury, Sumana
    George Town, KY1-1104 (KY)
  • Bruce, Andrew, T.
    Lexington, NC 27295 (US)
  • Genheimer, Christopher, W.
    Colfax, NC 27235 (US)
  • Cox, Bryan, R.
    Winston-Salem, NC 27104 (US)
  • Guthrie, Kelly, I.
    Winston-Salem, NC 27104 (US)
  • Basu, Joydeep
    George Town, KY1-1104 (US)
  • Wallace, Shay, M.
    Winston-Salem, NC 27127 (US)
  • Werdin, Eric, S.
    Lewisville, NC 27023 (US)
  • Knight, Oluwatoyin, A.
    Winston-Salem, NC 27127 (US)
  • Sangha, Namrata, D.
    Winston-Salem, NC 27104 (US)
  • Ludlow, John, W.
    Carrboro, NC 27510 (US)
  • Halberstadt, Craig, R.
    George Town, KY1-1104 (US)
  • Payne, Richard
    Winston-Salem, NC 27101 (US)
  • Robins, Neil, F., Jr.
    Winston-Salem, NC 27107 (US)
  • McCoy, Darrell
    Clemmons, NC 27012 (US)
  • Jain, Deepak
    Winston-Salem, NC 27104 (US)
  • Jayo, Manuel, J.
    Winston-Salem, NC 27104 (US)
  • Rivera, Elias, A.
    Oak Ridge, NC 27310 (US)
  • Spencer, Thomas
    Winston-Salem, NC 27103 (US)
  • Watts, Benjamin
    King, NC 27021 (US)

(74) Representative: Mewburn Ellis LLP 
Aurora Building Counterslip
Bristol BS1 6BX
Bristol BS1 6BX (GB)


(56) References cited: : 
WO-A1-2010/056328
JP-A- 2004 309 186
   
  • TUMLIN JAMES ET AL: "Efficacy and safety of renal tubule cell therapy for acute renal failure", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 19, no. 5, May 2008 (2008-05), pages 1034-1040, XP009150660, ISSN: 1046-6673
  • TAMER ABOUSHWAREB ET AL: "Erythropoietin producing cells for potential cell therapy", WORLD JOURNAL OF UROLOGY, SPRINGER, BERLIN, DE, vol. 26, no. 4, 8 July 2008 (2008-07-08), pages 295-300, XP019627203, ISSN: 1433-8726
  • JORAKU AKIRA ET AL: "In vitro generation of three-dimensional renal structures", METHODS : A COMPANION TO METHODS IN ENZYMOLOGY, ACADEMIC PRESS INC., NEW YORK, NY, US, vol. 47, no. 2, 1 February 2009 (2009-02-01), pages 129-133, XP002568576, ISSN: 1046-2023, DOI: DOI:10.1016/J.YMETH.2008.09.005 [retrieved on 2008-10-07]
  • KATO MITSUO ET AL: "MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 104, no. 9, February 2007 (2007-02), pages 3432-3437, XP009152739, ISSN: 0027-8424
  • SEQUEIRA-LOPEZ MARIA LUISA S ET AL: "The microRNA-processing enzyme dicer maintains juxtaglomerular cells.", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY : JASN MAR 2010 LNKD- PUBMED:20056748, vol. 21, no. 3, March 2010 (2010-03), pages 460-467, XP009152738, ISSN: 1533-3450
  • GILLES N CHIRONI ET AL: "Endothelial microparticles in diseases", CELL AND TISSUE RESEARCH, SPRINGER, BERLIN, DE, vol. 335, no. 1, 7 November 2008 (2008-11-07), pages 143-151, XP019658542, ISSN: 1432-0878
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).