| (19) |
 |
|
(11) |
EP 3 190 180 A3 |
| (12) |
EUROPEAN PATENT APPLICATION |
| (88) |
Date of publication A3: |
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09.08.2017 Bulletin 2017/32 |
| (43) |
Date of publication A2: |
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12.07.2017 Bulletin 2017/28 |
| (22) |
Date of filing: 08.08.2008 |
|
| (51) |
International Patent Classification (IPC):
|
|
| (84) |
Designated Contracting States: |
|
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL
PT RO SE SI SK TR |
| (30) |
Priority: |
10.08.2007 EP 07114192
|
| (62) |
Application number of the earlier application in accordance with Art. 76 EPC: |
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08793835.3 / 2190978 |
| (71) |
Applicant: Koninklijke Nederlandse Akademie van Wetenschappen |
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3584 CT Utrecht (NL) |
|
| (72) |
Inventors: |
|
- CLEVERS, Johannes Carolus
3712 AP Huis Ter Heide (NL)
- BARKER, Nicholas
3522 HX Utrecht (NL)
- HAEGEBARTH, Andrea
13347 Berlin (DE)
- VAN DE WETERING, Marcus Lambertus
3993 DA Houten (NL)
|
| (74) |
Representative: Goodfellow, Hugh Robin |
|
Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA
London WC1B 5HA (GB) |
|
| |
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| (54) |
A METHOD FOR IDENTIFYING, EXPANDING, AND REMOVING ADULT STEM CELLS AND CANCER STEM
CELLS |
(57) The invention relates to the fields of biochemistry, pharmacy and oncology. The invention
particularly relates to the use of novel stem cell markers for the isolation of stem
cells. The invention further relates to the obtained stem cells and their use in for
example research or treatment, for example, for the preparation of a medicament for
the treatment of damaged or diseased tissue. In one of the embodiments, the invention
provides a method for obtaining (or isolating) stem cells comprising optionally preparing
a cell suspension from a tissue or organ sample, contacting said cell suspension with
an Lgr 6 or 5 binding compound, identify the cells bound to said binding compound,
and optionally isolating the stem cells from said binding compound. The invention
further relates to means suitable for cancer treatment and even more specific for
the treatment of cancer by eradicating cancer stem cells.