HIGH AFFINITY AND AGGREGATIVELY STABLE ANTIBODIES ON THE BASIS OF VARIABLE DOMAINS VL AND A DERIVATIVE VHH

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EP 3 199 550 B8

(12)	CORRECTED EUROPEAN PATENT SPECIFICATION
	Note: Bibliography reflects the latest situation

(15)	Correction information:
	Corrected version no 1 (W1 B1)

(48)	Corrigendum issued on:
	14.05.2025 Bulletin 2025/20

(45)	Mention of the grant of the patent:
	05.03.2025 Bulletin 2025/10

(21)	Application number: 15843607.1

(22)	Date of filing: 23.03.2015

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International Patent Classification (IPC):

C07K 16/24^(2006.01)
C12N 15/13^(2006.01)
A61K 45/06^(2006.01)

C07K 16/18^(2006.01)
A61K 39/395^(2006.01)

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Cooperative Patent Classification (CPC):

C07K 2317/22; C07K 2317/567; C07K 2317/94; A61K 45/06; C07K 16/244; C07K 2317/24; C07K 2317/565; C07K 2317/76; C07K 2317/92; A61P 1/04; A61P 1/16; A61P 1/18; A61P 11/00; A61P 11/02; A61P 11/06; A61P 13/08; A61P 13/12; A61P 15/00; A61P 15/08; A61P 17/00; A61P 17/02; A61P 17/04; A61P 17/06; A61P 19/02; A61P 19/10; A61P 21/04; A61P 25/00; A61P 25/04; A61P 25/06; A61P 25/10; A61P 25/14; A61P 25/16; A61P 25/18; A61P 25/22; A61P 25/24; A61P 25/28; A61P 25/30; A61P 25/32; A61P 27/02; A61P 29/00; A61P 31/04; A61P 31/06; A61P 31/10; A61P 31/14; A61P 31/18; A61P 31/20; A61P 33/02; A61P 35/00; A61P 35/02; A61P 3/08; A61P 37/00; A61P 37/02; A61P 37/06; A61P 37/08; A61P 43/00; A61P 5/14; A61P 5/18; A61P 7/00; A61P 7/02; A61P 7/04; A61P 7/06; A61P 9/00; A61P 9/04; A61P 9/06; A61P 9/08; A61P 9/10; A61P 3/10

(86)	International application number:
	PCT/RU2015/000163

(87)	International publication number:
	WO 2016/048188 (31.03.2016 Gazette 2016/13)

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HIGH AFFINITY AND AGGREGATIVELY STABLE ANTIBODIES ON THE BASIS OF VARIABLE DOMAINS VL AND A DERIVATIVE VHH

HOCHAFFINE UND AGGREGATIV STABILE ANTIKÖRPER AUF DER BASIS VON VL MIT VARIABLEN DOMÄNEN UND VHH-DERIVAT

ANTICORPS STABLES À AFFINITÉ ÉLEVÉE ET AGRÉGATIFS À BASE DE DOMAINES VIRAUX VL ET DE DÉRIVÉ DE VHH

(84)	Designated Contracting States:
	AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
	Designated Validation States:
	MA

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Priority:

26.09.2014 RU 2014138740

(43)	Date of publication of application:
	02.08.2017 Bulletin 2017/31

(73)	Proprietor: Joint Stock Company "Biocad"
	Saint Petersburg 198515 (RU)

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Inventors:

ULITIN, Andrey Borisovich
Moskovskaya obl. g. Puschino 142290 (RU)
EVDOKIMOV, Stanislav Rudolfovich
Moskovskaya obl. g. Puschino 142290 (RU)
SOLOVIEV, Valeriy Vladimirovich
Moskovskaya obl. g. Puschino 119071 (RU)
CHERNYH, Yulia Sergeevna
Permsky krai g. Solikamsk 618553 (RU)
GONCHAROVA, Olga Vladimirovna
Moskovskaya obl. Chekhovsky r-on pos. Lyubuchany 142380 (RU)
KORZHAVIN, Dmitriy Valerievich
St.Petersburg 192284 (RU)
CHERNOVSKAYA, Tatyana Veniaminovna
Moskovskaya obl. Chekhovsky r-on pos. Lyubuchany 142380 (RU)
NEMANKIN, Timofey Aleksandrovich
St.Petersburg 198099 (RU)
IVANOV, Roman Alexeevich
Moscow 125167 (RU)
MOROZOV, Dmitriy Valentinovich
Moscow 119071 (RU)
EKIMOVA, Victoria Mikhailovna
Tyumen 625022 (RU)
SOFRONOVA, Ekaterina Vladimirovna
The Republic of Tatarstan Kazan 420136 (RU)
USTYUGOV, Yakov Yurevich
Perm obl. Berezniki 618426 (RU)

(74)	Representative: Meissner Bolte Partnerschaft mbB
	Patentanwälte Rechtsanwälte Postfach 86 06 24 81633 München 81633 München (DE)

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References cited: :

WO-A1-2012/156219
US-A1- 2012 225 065

RU-C2- 2 426 741
US-A1- 2014 205 613

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PETER BANNAS ET AL: "Nanobodies and Nanobody-Based Human Heavy Chain Antibodies As Antitumor Therapeutics", FRONTIERS IN IMMUNOLOGY, vol. 8, 22 November 2017 (2017-11-22), CH, XP055454260, ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.01603
S. MUYLDERMANS ET AL.: "Recognition of antigens by single-domain antibody fragments: the superfluous luxury of paired domains", TRENDS IN BIOCHEMICAL SCIENCES, vol. 26, no. 4, 2001, pages 230 - 235, XP004241851, DOI: doi:10.1016/S0968-0004(01)01790-X
K. CONRATH ET AL.: "Antigen Binding and Solubility Effects upon the Veneering of a Camel VHH in Framework-2 to Mimic a VH", J. MOL. BIOL., vol. 350, 2005, pages 112 - 125, XP004918534, DOI: doi:10.1016/j.jmb.2005.04.050

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