(19)
(11) EP 3 205 718 A8

(12) CORRECTED EUROPEAN PATENT APPLICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 A1)

(48) Corrigendum issued on:
04.04.2018 Bulletin 2018/14

(43) Date of publication:
16.08.2017 Bulletin 2017/33

(21) Application number: 16155748.3

(22) Date of filing: 15.02.2016
(51) International Patent Classification (IPC): 
C12N 5/078(2010.01)
C12N 5/0789(2010.01)
C07K 14/47(2006.01)
 C12N 5/077(2010.01)
C12N 5/071(2010.01)
C07K 14/46(2006.01)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
MA MD

(71) Applicant: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
80539 München (DE)

(72) Inventors:
  • REISCHAUER, Sven
    61231 Bad Nauheim (DE)
  • STAINIER, Didier
    61381 Friedrichsdorf (DE)
  • VILLASENOR, Alethia
    61231 Bad Nauheim (DE)
  • STONE, Oliver Andrew
    61231 Bad Nauheim (DE)

(74) Representative: Vossius & Partner Patentanwälte Rechtsanwälte mbB 
Siebertstrasse 3
81675 München
81675 München (DE)

   


(54) MEANS AND METHODS FOR CELL DIFFERENTIATION


(57) The present invention relates to a method for producing endothelial cells from progenitor cells, said method comprising inducing NPAS4 function in the progenitor cells. The present invention also encompasses a method for producing hematopoietic cells from progenitor cells, said method comprising inducing NPAS4 function in the progenitor cells. The present invention furthermore pertains to a method for producing cardiomyocytes from progenitor cells, said method comprising inhibiting NPAS4 function in the progenitor cell.