PRODUCTION METHOD FOR NERVE TISSUE

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EP 3 211 072 B8

(12)	CORRECTED EUROPEAN PATENT SPECIFICATION
	Note: Bibliography reflects the latest situation

(15)	Correction information:
	Corrected version no 1 (W1 B1)

(48)	Corrigendum issued on:
	21.05.2025 Bulletin 2025/21

(45)	Mention of the grant of the patent:
	09.04.2025 Bulletin 2025/15

(21)	Application number: 15852504.8

(22)	Date of filing: 23.10.2015

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International Patent Classification (IPC):

C12N 5/079^(2010.01)
A61K 35/12^(2015.01)
A61L 27/00^(2006.01)
C12Q 1/02^(2006.01)
G01N 33/50^(2006.01)

C12N 5/0793^(2010.01)
A61K 35/30^(2015.01)
A61P 25/00^(2006.01)
A61L 27/38^(2006.01)

(52)	Cooperative Patent Classification (CPC):
	A61L 27/00; A61K 35/12; A61K 35/30; C12Q 1/02; C12N 5/0619; C12N 2500/99; C12N 2501/15; C12N 2501/16; C12N 2501/41; C12N 2501/415; C12N 2501/727; C12N 2533/52; C12N 2501/115; C12N 2501/155; C12N 2506/45; A61P 25/00; A61P 27/02

(86)	International application number:
	PCT/JP2015/080016

(87)	International publication number:
	WO 2016/063985 (28.04.2016 Gazette 2016/17)

(54)	PRODUCTION METHOD FOR NERVE TISSUE HERSTELLUNGSVERFAHREN FÜR NERVENGEWEBE PROCÉDÉ DE PRODUCTION DE TISSU NERVEUX

(84)	Designated Contracting States:
	AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

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Priority:

24.10.2014 JP 2014217867

(43)	Date of publication of application:
	30.08.2017 Bulletin 2017/35

(73)	Proprietors:
	RACTHERA Co., Ltd. Tokyo 103-6012 (JP) RIKEN Wako-shi, Saitama 351-0198 (JP)

(72)	Inventors:
	KUWAHARA, Atsushi Kobe-shi Hyogo 650-0047 (JP) YAMASAKI, Suguru Kobe-shi Hyogo 650-0047 (JP) HIRAMINE, Yasushi Kobe-shi Hyogo 658-0072 (JP) SASAI, Yoshiki deceased (JP) TAKAHASHI, Masayo Wako-shi Saitama 351-0198 (JP)

(74)	Representative: J A Kemp LLP
	80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)

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References cited: :

EP-A1- 2 784 152
JP-A- 2012 245 007

WO-A1-2013/077425
JP-A- 2013 099 345

M. W. AMOROSO ET AL: "Accelerated High-Yield Generation of Limb-Innervating Motor Neurons from Human Stem Cells", JOURNAL OF NEUROSCIENCE, vol. 33, no. 2, 9 January 2013 (2013-01-09), pages 574 - 586, XP055149810, ISSN: 0270-6474, DOI: 10.1523/JNEUROSCI.0906-12.2013
OSAKADA FUMITAKA ET AL: "In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction", JOURNAL OF CELL SCIENCE, CAMBRIDGE UNIVERSITY PRESS, LONDON, GB, vol. 122, no. 17, 1 September 2009 (2009-09-01), pages 3169 - 3179, XP002604161, ISSN: 0021-9533, DOI: 10.1242/JCS.050393
IRENE FARAVELLI ET AL: "Motor neuron derivation from human embryonic and induced pluripotent stem cells: experimental approaches and clinical perspectives", STEM CELL RESEARCH & THERAPY, BIOMED CENTRAL LTD, LONDON, UK, vol. 5, no. 4, 14 July 2014 (2014-07-14), pages 87, XP021208904, ISSN: 1757-6512, DOI: 10.1186/SCRT476
B. N. DAVIS-DUSENBERY ET AL: "How to make spinal motor neurons", DEVELOPMENT, vol. 141, no. 3, 21 January 2014 (2014-01-21), GB, pages 491 - 501, XP055501768, ISSN: 0950-1991, DOI: 10.1242/dev.097410
B.-Y. HU ET AL: "Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 107, no. 9, 2 March 2010 (2010-03-02), pages 4335 - 4340, XP055068931, ISSN: 0027-8424, DOI: 10.1073/pnas.0910012107
OSAKADA F. ET AL.: "Neural Induction and Patterning in Mammalian Pluripotent Stem Cells, CNS & Neurological Disorders", DRUG TARGETS, vol. 10, no. 4, 2011, pages 419 - 432, XP009502411
OZAIR M. Z. ET AL.: "Neural induction and early patterning in vertebrates", WIRES DEV BIOL., vol. 2, 2013, pages 479 - 498, XP055434370
MUGURUMA K. ET AL.: "Ontogeny-recapitulating generation and tissue integration of ES cell derived Purkinje cells", NATURE NEUROSCIENCE, vol. 13, no. 10, 2010, pages 1171 - 1180, XP055059517, DOI: doi:10.1038/nn.2638
YOSHIKI SASAI: "Shinkei-kei Soshiki no Pattern Keisei ni Miru Jiko Soshikika: Sohatsu Seibutsugaku eno Chosen", BRAIN SCIENCE REVIEW, February 2014 (2014-02-01), pages 99 - 112, XP008185658

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