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EP 3 211 997 A1

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(43) Date of publication: 06.09.2017 Bulletin 2017/36 (21) Application number: 15848340.4 (22) Date of filing: 08.10.2015

(51) International Patent Classification (IPC):  A01N 43/02(2006.01) A61K 31/365(2006.01) A61K 31/335(2006.01) (86) International application number: PCT/US2015/054700 (87) International publication number: WO 2016/057798 (14.04.2016 Gazette 2016/15)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA (30) Priority: 08.10.2014 US 201462061571 P (71) Applicant: President and Fellows of Harvard College Cambridge, MA 02138 (US)	(72) Inventors: MYERS, Andrew G. Boston, MA 02116 (US) SEIPLE, Ian Bass San Francisco, CA 94158 (US) ZHANG, Ziyang Boston, MA 02215 (US) (74) Representative: Crooks, Elizabeth Caroline et al Kilburn & Strode LLP 20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)