(19)
(11) EP 3 215 526 A1

(12)

(43) Date of publication:
13.09.2017 Bulletin 2017/37

(21) Application number: 15802233.5

(22) Date of filing: 05.11.2015
(51) International Patent Classification (IPC): 
C07K 16/00(2006.01)
C07K 16/46(2006.01)
 C07K 16/24(2006.01)
(86) International application number:
PCT/US2015/059339
(87) International publication number:
WO 2016/073791 (12.05.2016 Gazette 2016/19)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
MA MD

(30) Priority: 05.11.2014 US 201462075792 P
20.08.2015 US 201562207882 P

(71) Applicant: F. Hoffmann-La Roche AG
4070 Basel (CH)

(72) Inventors:
  • GIULIANOTTI, James
    South San Francisco, CA 94080-4990 (US)
  • REILLY, Dorothea
    South San Francisco, CA 94080-4990 (US)

(74) Representative: Klaus, Michaela 
F. Hoffmann-La Roche AG Patent Department Grenzacherstrasse 124
4070 Basel
4070 Basel (CH)

   


(54) METHODS OF PRODUCING TWO CHAIN PROTEINS IN BACTERIA