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EP 3 221 358 A1

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(43) Date of publication: 27.09.2017 Bulletin 2017/39 (21) Application number: 15801630.3 (22) Date of filing: 17.11.2015

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) A61P 35/00(2006.01) A61K 39/395(2006.01) (86) International application number: PCT/US2015/061014 (87) International publication number: WO 2016/081423 (26.05.2016 Gazette 2016/21)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 18.11.2014 US 201462081134 P (71) Applicant: Janssen Pharmaceutica, N.V. 2340 Beerse (BE)	(72) Inventors: DONG, Jianying San Diego, CA 92121 (US) CARDOSO, Rosa Spring House, PA 19477 (US) ZHOU, Hong, Mimi San Diego, CA 92121 (US) PIETSCH, Christine Spring House, PA 19477 (US) (74) Representative: Cornish, Kristina Victoria Joy et al Kilburn & Strode LLP 20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)