(19)
(11) EP 3 222 993 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
26.02.2020 Bulletin 2020/09

(45) Mention of the grant of the patent:
11.12.2019 Bulletin 2019/50

(21) Application number: 15861543.5

(22) Date of filing: 20.11.2015
(51) International Patent Classification (IPC): 
C12Q 1/689(2018.01)
G01N 19/00(2006.01)
G01N 11/16(2006.01)
G01N 33/483(2006.01)
C12Q 1/6825(2018.01)
G01N 11/00(2006.01)
B01L 3/00(2006.01)
G01N 33/487(2006.01)
(86) International application number:
PCT/JP2015/082789
(87) International publication number:
WO 2016/080543 (26.05.2016 Gazette 2016/21)

(54)

MOLECULE DETECTION SYSTEM

SYSTEM FÜR DEN NACHWEIS VON MOLEKÜLEN

SYSTÈME DE DÉTECTION DE MOLÉCULE


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 21.11.2014 JP 2014236193

(43) Date of publication of application:
27.09.2017 Bulletin 2017/39

(73) Proprietor: Centre National de la Recherche Scientifique
75016 Paris (FR)

(72) Inventors:
  • FUJITA Hiroyuki
    Tokyo 153-8505 (JP)
  • TARHAN Mehmet Cagatay
    Tokyo 153-8505 (JP)
  • LAFITTE Nicolas
    33160 Saint-Médard-en-Jalles (FR)
  • COLLARD Dominique
    Tokyo 153-8505 (JP)

(74) Representative: Regimbeau 
87 rue de Sèze
69477 Lyon Cedex 06
69477 Lyon Cedex 06 (FR)


(56) References cited: : 
WO-A1-2010/144157
WO-A1-2014/069551
WO-A2-00/68419
US-A1- 2014 150 522
WO-A1-2014/018558
WO-A1-2014/072397
US-A1- 2007 023 621
   
  • KUMEMURA M ET AL: "Direct bio-mechanical sensing of enzymatic reaction On DNA by silicon nanotweezers", MICRO ELECTRO MECHANICAL SYSTEMS (MEMS), 2010 IEEE 23RD INTERNATIONAL CONFERENCE ON, IEEE, PISCATAWAY, NJ, USA, 24 January 2010 (2010-01-24), pages 915-918, XP031655076, ISBN: 978-1-4244-5761-8
  • N LAFITTE ET AL: "REAL-TIME SENSING OF MOLECULE BINDING ON DNA WITH SILICON NANOTWEEZERS", CHEMICAL SOCIETY REVIEWS, 2 October 2011 (2011-10-02), pages 389-391, XP055445478, ISSN: 0306-0012
  • MEHMET C. TARHAN ET AL: "A rapid and practical technique for real-time monitoring of biomolecular interactions using mechanical responses of macromolecules", SCIENTIFIC REPORTS, vol. 6, no. 1, 16 June 2016 (2016-06-16), XP055485557, DOI: 10.1038/srep28001
  • KUMEMURA M. ET AL.: 'DIRECT BIO-MECHANICAL SENSING OF ENZYMATIC REACTION ON DNA BY SILICON NANOTWEEZERS' MICRO ELECTRO MECHANICAL SYSTEMS (MEMS), 2010 IEEE 23RD INTERNATIONAL CONFERENCE 24 January 2010, pages 915 - 918, XP031655076
  • LAFITTE N. ET AL.: 'REAL-TIME SENSING OF MOLECULE BINDING ON DNA WITH SILICON NANOTWEEZERS' 15TH INTERNATIONAL CONFERENCE ON MINIATURIZED SYSTEMS FOR CHEMISTRY AND LIFE SCIENCES 02 October 2011, pages 389 - 391, XP055445478
  • PO-TSUN CHIANG ET AL.: 'REAL-TIME MEASUREMENT OF DNA DEGRADATION UNDER RADIATION BY SILICON NANOTWEEZERSCOUPLED WITH MICROFLUIDIC CAVITY' THE PAPERS OF TECHNICAL MEETING ON BIO MICRO SYSTEMS vol. 66, no. 3, 01 January 2014, pages 285 - 290, XP055445525
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).