(19)
(11) EP 3 227 830 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
01.07.2020 Bulletin 2020/27

(45) Mention of the grant of the patent:
20.05.2020 Bulletin 2020/21

(21) Application number: 15813713.3

(22) Date of filing: 03.12.2015
(51) International Patent Classification (IPC): 
G06T 7/11(2017.01)
G06K 9/00(2006.01)
G06T 7/90(2017.01)
G06K 9/62(2006.01)
(86) International application number:
PCT/EP2015/078532
(87) International publication number:
WO 2016/087589 (09.06.2016 Gazette 2016/23)

(54)

METHODS, SYSTEMS, AND APPARATUSES FOR QUANTITATIVE ANALYSIS OF HETEROGENEOUS BIOMARKER DISTRIBUTION

VERFAHREN, SYSTEME UND VORRICHTUNGEN ZUR QUANTITATIVEN ANALYSE VON HETEROGENER BIOMARKERVERTEILUNG

PROCÉDÉS, SYSTÈMES ET APPAREILS POUR UNE ANALYSE QUANTITATIVE D'UNE DISTRIBUTION DE MARQUEUR BIOLOGIQUE HÉTÉROGÈNE


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 03.12.2014 US 201462086840 P

(43) Date of publication of application:
11.10.2017 Bulletin 2017/41

(73) Proprietors:
  • Ventana Medical Systems, Inc.
    Tucson, Arizona 85755 (US)
  • Oregon Health & Science University
    Portland, OR 97201-4753 (US)

(72) Inventors:
  • BARNES, Michael
    Oro Valley, Arizona 85737 (US)
  • CHAFIN, David
    Tucson, Arizona 85755 (US)
  • GARSHA, Karl
    Sahuarita, Arizona 85629 (US)
  • GROGAN, Thomas M.
    Tucson, Arizona 85718 (US)
  • ROBERTS, Esteban
    Tucson, Arizona 85742 (US)
  • STEVENS, Benjamin
    Oro Valley, Arizona 85755 (US)
  • VENTURA, Frank
    Tucson, Arizona 85735 (US)
  • CHEFD'HOTEL, Christophe
    San Jose , California 95112 (US)
  • SHANMUGAM, Kandavel
    Chandler, Arizona 85226 (US)
  • GRAY, Joe
    Lake Oswego, Arizona 97034 (US)
  • RAMUNNO-JOHNSON, Damien
    Oakland, CA 94611 (US)
  • VU, Tothu (Tania)
    Portland, OR 97201 (US)
  • DRUKER, Brian Jay
    97201 Portland (US)
  • JACOB, Thomas
    97201 Portland (US)

(74) Representative: Richardt Patentanwälte PartG mbB 
Wilhelmstraße 7
65185 Wiesbaden
65185 Wiesbaden (DE)


(56) References cited: : 
   
  • RICHARD LEVENSON ET AL: "Spectral imaging in preclinical research and clinical pathology", ANALYTICAL CELLULAR PATHOLOGY (AMSTERDAM), vol. 35, no. 5-6, 4 April 2012 (2012-04-04), pages 339-361, XP055114008, Netherlands DOI: 10.3233/ACP-2012-0062
  • XAVIER MOLES LOPEZ ET AL: "Clustering methods applied in the detection of Ki67 hot-spots in whole tumor slide images: An efficient way to characterize heterogeneous tissue-based biomarkers", CYTOMETRY. PART A, vol. 81A, no. 9, 22 June 2012 (2012-06-22) , pages 765-775, XP055249483, US ISSN: 1552-4922, DOI: 10.1002/cyto.a.22085
  • CHEN Y ET AL: "Automated 5-D analysis of cell migration and interaction in the thymic cortex from time-lapse sequences of 3-D multi-channel multi-photon images", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 340, no. 1, 1 January 2009 (2009-01-01), pages 65-80, XP025991301, ISSN: 0022-1759, DOI: 10.1016/J.JIM.2008.09.024 [retrieved on 2008-11-04]
   
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