(19)
(11) EP 3 230 312 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
20.03.2024 Bulletin 2024/12

(45) Mention of the grant of the patent:
24.01.2024 Bulletin 2024/04

(21) Application number: 15816210.7

(22) Date of filing: 10.12.2015
(51) International Patent Classification (IPC): 
C07K 16/00(2006.01)
(52) Cooperative Patent Classification (CPC):
C07K 2317/10; C07K 2317/20; C07K 2317/515; C07K 16/00
(86) International application number:
PCT/GB2015/053787
(87) International publication number:
WO 2016/092315 (16.06.2016 Gazette 2016/24)

(54)

A METHOD FOR PRODUCING A RECOMBINANT ALLOTYPESPECIFIC RABBIT MONOCLONAL ANTIBODY

VERFAHREN ZUR HERSTELLUNG EINES REKOMBINANTEN ALLOTYP-SPEZIFISCHEN MONOKLONALEN KANINCHENANTIKÖRPERS

PROCÉDÉ DE PRODUCTION D'ANTICORPS MONOCLONAL DE LAPIN RECOMBINÉ SPÉCIFIQUE D'UN ALLOTYPE


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 11.12.2014 GB 201422075

(43) Date of publication of application:
18.10.2017 Bulletin 2017/42

(73) Proprietor: ABCAM LIMITED
Cambridge CB2 0AX (GB)

(72) Inventor:
  • COUTO, Fernando Jose Rebelo Do
    Cambridge CB2 0AX (GB)

(74) Representative: Boult Wade Tennant LLP 
Salisbury Square House 8 Salisbury Square
London EC4Y 8AP
London EC4Y 8AP (GB)


(56) References cited: : 
US-B2- 7 429 487
   
  • SPIEKER-POLET H ET AL: "RABBIT MONOCLONAL ANTIBODIES: GENERATING A FUSION PARTNER TO PRODUCE RABBIT-RABBIT HYBRIDOMAS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 92, 1 September 1995 (1995-09-01), pages 9348-9352, XP001016241, ISSN: 0027-8424, DOI: 10.1073/PNAS.92.20.9348 cited in the application
  • STEFAN SEEBER ET AL: "A Robust High Throughput Platform to Generate Functional Recombinant Monoclonal Antibodies Using Rabbit B Cells from Peripheral Blood", PLOS ONE, vol. 9, no. 2, 4 February 2014 (2014-02-04), pages e86184/-14, XP055128871, US ISSN: 1932-6203, DOI: 10.1371/journal.pone.0086184
  • WOLF B ET AL: "Identification of rabbit immunoglobulin latent Ckappa1 allotype genes alters the concept of allelic inheritance.", MOLECULAR IMMUNOLOGY OCT 1998, vol. 35, no. 14-15, October 1998 (1998-10) , pages 965-976, XP002755297, ISSN: 0161-5890
  • AKIMENKO M-A ET AL: "Complex allotypes of the rabbit immunoglobulin kappa light chains are encoded by structural alleles", NUCLEIC ACIDS RESEARCH, INFORMATION RETRIEVAL LTD, GB, vol. 12, no. 11, 1 January 1984 (1984-01-01), pages 4691-4701, XP002273991, ISSN: 0305-1048
  • DREHER K L ET AL: "cDNA clone encoding a complete rabbit immunoglobulin kappa light chain of b4 allotype", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 80, no. 14, 1 July 1983 (1983-07-01), pages 4489-4493, XP002346543, ISSN: 0027-8424, DOI: 10.1073/PNAS.80.14.4489
  • VAN DER LOO W ET AL: "The allotypic patchwork pattern of the rabbit IGKC1 allele b5wf: genic exchange or common ancestry?", IMMUNOGENETICS JAN 1999, vol. 49, no. 1, January 1999 (1999-01), pages 7-14, XP009188975, ISSN: 0093-7711
  • DATABASE REGISTRY [Online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 7 March 2005 (2005-03-07), XP002755298, Database accession no. 843725-58-6
  • DATABASE REGISTRY [Online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 9 December 2004 (2004-12-09), XP002755299, Database accession no. 795419-85-1
  • DATABASE REGISTRY [Online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 4 August 2004 (2004-08-04), XP002755300, Database accession no. 722438-22-4
  • COUTO ET AL: "Cloning of cDNAs encoding the variable domains of antibody KC4G3 and construction of a chimeric antibody", HYBRIDOMA, LIEBERT, NEW YORK, NY, US, vol. 4, no. 12, 1 September 1993 (1993-09-01), pages 485-489, XP002077920, ISSN: 0272-457X
   
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